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BioMed Research International
Volume 2015, Article ID 817427, 4 pages
Research Article

Anti-CCP Antibody Levels Are Not Associated with MS: Results from a Case-Control Study

1Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Yuzuncu Yil University, 65100 Van, Turkey
2Department of Neurology, Faculty of Medicine, Yuzuncu Yil University, 65100 Van, Turkey
3Department of Medical Microbiology, Faculty of Medicine, Yuzuncu Yil University, 65100 Van, Turkey

Received 23 July 2014; Revised 26 October 2014; Accepted 11 November 2014

Academic Editor: Bruce V. Taylor

Copyright © 2015 Mahmut Alpayci et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Citrullinated proteins have been suggested to play a critical role in the pathogenesis of multiple sclerosis (MS). Anticyclic citrullinated peptide (anti-CCP) antibody is used in the early diagnosis of rheumatoid arthritis (RA). The objective of this study was to investigate the presence of anti-CCP antibody in patients with MS compared to RA patients and healthy controls. Fifty patients with MS (38 females, 12 males; mean age 36.72 ± 8.82 years), 52 patients with RA (40 females, 12 males; mean age 40.87 ± 10.17 years), and 50 healthy controls (32 females, 18 males; mean age 38.22 ± 11.59 years) were included in this study. The levels of serum anti-CCP antibody were measured using an enzyme-linked immunosorbent assay (ELISA). The results of the study showed that anti-CCP antibody levels were significantly higher in RA patients versus MS or healthy controls . Moreover, anti-CCP antibody was positive in 43 (83%) patients with RA, while it was negative in all MS patients as well as in all healthy controls. Also, no significant correlation was found between the anti-CCP levels and EDSS scores . In conclusion, the results of this study did not support a positive association between serum anti-CCP antibody and MS.