Cortical Structural Connectivity Alterations in Primary Insomnia: Insights from MRI-Based Morphometric Correlation Analysis

Figure 2

Between-group comparison of structural covariance seeded from the left primary visual cortex (PVC). (a) Structural covariance maps in healthy controls (HC) and patients with primary insomnia (PI). Seed region is colored in blue. (b) Increased left PVC-cortical network covariance in PI. Patients showed trends of increased covariance between the left PVC and the medial motor areas, the left dorsal parietooccipital region, the left cuneus, the right PHG, and the right ITC (, uncorrected). (c) Decreased left PVC-cortical network covariance in PI. Patients showed trends of decreased covariance between the left PVC and the lateral PFC, the IPC, the LOC, the left STC, the left dmPFC, and the right IFGoperc (, uncorrected). Scatter plots illustrate slope differences in selected vertices, where adjusted cortical thickness values and regression lines are shown in red for patients and in blue for controls.

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