Cortical Structural Connectivity Alterations in Primary Insomnia: Insights from MRI-Based Morphometric Correlation Analysis

Figure 7

Between-group comparison of structural covariance seeded from the right olfactory cortex (OLF). (a) Structural covariance maps in healthy controls (HC) and patients with primary insomnia (PI). Seed region is colored in blue. (b) Increased right OLF-cortical network covariance in PI. Patients showed significantly increased correlation between the right OLF and the left cuneus (, RFT-cluster corrected), and trends of increased correlations with the dorsal central areas, the medial motor areas (PCL/SMA), the PHG, the medial occipital lobes, the dorsal parietooccipital regions, the right inferior occipital gyrus, and the right primary auditory cortex (HES) (, uncorrected). (c) Decreased right OLF-cortical network covariance in PI. Patients showed trends of increased correlations between the right OLF and the lateral PFC, the IFGoperc, the IPC, the left LTC, and the right dmPFC (, uncorrected). Scatter plots illustrate slope differences in selected vertices, where adjusted cortical thickness values and regression lines are shown in red for patients and in blue for controls.

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