Immunotherapy for Bone and Soft Tissue Sarcomas

Figure 1

An overview of tumor immunology. Tumor cells are initially attacked by the innate immune system. DCs capture tumor antigens at the tumor site and migrate to the tumor draining lymph nodes. DCs present the tumor antigen to T cells within the lymph node. Antigen-specific CD4 and CD8 T cells are stimulated by DCs. After stimulation, T cells differentiate into effector cells and activate at the tumor site. Effector CD8 T cells kill tumor cells, although their function is regulated by the immune checkpoint mechanism. NK: natural killer cell; MP: macrophage; DC: dendritic cell.