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BioMed Research International
Volume 2015, Article ID 821761, 19 pages
Research Article

Gene Network Analysis of Glucose Linked Signaling Pathways and Their Role in Human Hepatocellular Carcinoma Cell Growth and Survival in HuH7 and HepG2 Cell Lines

1Lyon University, INSERM, UMR1060, INRA1397, CarMeN Laboratory, INSA, HCL, 69008 Lyon, France
2Lyon University, Centre de Génétique et de Physiologie Moléculaire et Cellulaire (CGPhiMC), CNRS UMR5534, 69622 Lyon, France

Received 5 January 2015; Accepted 6 March 2015

Academic Editor: Ming Wu

Copyright © 2015 Emmanuelle Berger et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Suppl Information 1 : Gene datasets regulated by intracellular pathways (left panel) and transcrition factors (right panel).

Suppl Information 2: Hepatic genes differentially expressed in Hepg2 versus HuH7 cells (red: up-regulated, green: down-regulated). Genes present in hepatocellularcarcinoma gene sets are in yellow. IL6R is a unique gene regulated by glucose (27).

  1. Supplementary Material