MicroRNAs as Regulator of Signaling Networks in Metastatic Colon Cancer

Table 2

Key signal pathways in metastatic colon cancer targeted by microRNAs.

MicroRNA	Signal pathway	References
miR-141	EMT	[68]
miR-15a	EMT	[31]
miR-16-1	EMT	[31]
miR-200c	EMT	[8]
let-7	EMT	[100]
miR-126	RhoA/ROCK, VEGF, and PI3K-AKT	[37, 42]
miR-135b	Wnt/β-catenin	[101, 102]
miR-143	HGF/MET and EGFR	[57]
miR-144	mTOR	[103]
miR-145	EGFR	[59]
miR-17-92	PI3K	[18]
miR-18a	Autophagy pathway	[69]
miR-185	HIF-2α	[104]
miR-196a	AKT	[105]
miR-21	Autophagy and stemness pathways	[27, 66]
miR-34a	Fra-1, E2F, and SIRT1-p53	[106]
miR-18	EGFR and KRAS	[107]
miR-30a	PI3K	[108]
miR-32	PTEN	[41]
miR-129	KRAS	[109]
miR-125b	p53	[110]
miR-155	PTEN	[111]
miR-203	EGFR and AKT	[112]
miR-223	PTEN	[113]
miR-525	PI3K	[114]