Inhibitory Effect of Various Breads on DMH-Induced Aberrant Crypt Foci and Colorectal Tumours in Rats

Figure 2

DMH-induced ACF and colorectal tumours in rats treated with DMH. (A) ACF expression in the colon of rats treated with DMH and stained with 0.5% methylene blue. (a) ACF expression in the colon from a rat of the Steinmetz Three-Grain bread group. Arrows point to two and three crypts in the colon. (b) ACF expression in the colon from a rat of the Steinmetz Country bread group. Arrows point to two and three crypts in the colon. (c) ACF expression in the colon from a rat of the White bread group. Arrows point to multiple crypts in the colon. (d) ACF expression in the colon from a rat of the MF diet group. Arrows point to multiple crypts in the colon. (B) DMH-induced colorectal tumours in rat. (a) Adenoma with mild dysplasia. (b) Adenoma with severe dysplasia. (c) Well differentiated tubular adenocarcinomas. (d) Moderately differentiated tubular adenocarcinomas. (e) Poorly differentiated adenocarcinomas. (f) Mucinous adenocarcinomas. Hematoxylin and eosin stains.