CMP-Neu5Ac Hydroxylase Null Mice as a Model for Studying Metabolic Disorders Caused by the Evolutionary Loss of Neu5Gc in Humans

Figure 3

Alteration of genes and miRNAs involved in metabolism-related pathways by CMAH disruption. (a) Comparison of the relative expressions of 84 genes involved in glucose metabolism between WT and Cmah-null mouse-derived liver tissues using a pathway-focused glucose metabolism PCR array. The figure depicts a scatter plot of the relative expression levels. Red and green colors indicate upregulation and downregulation of gene expression (>1.5-fold change), respectively. (b) Comparison of the relative expression levels of the 84 most abundantly expressed and best characterized miRNAs in miRBase using a miFinder miScript miRNA PCR Array. The figure depicts a scatter plot of the relative expression levels. Red and green colors indicate upregulation and downregulation of miRNA expression (>1.5-fold change). (c) Metabolism-related pathways and target molecules identified in liver tissues of Cmah-null mice. (d) miRNAs and target genes involved in glucose and glycogen metabolism. (e) Illustration of genes involved in glucose metabolism identified by the PCR array. Red and blue colors indicate upregulated genes and downregulated miRNAs, respectively.

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