Biological Roles of Resolvins and Related Substances in the Resolution of Pain

Table 1

Summary of important antinociceptive actions of resolvins in various pain models.

Resolvins		Genus	Pain models	Pain symptoms that were improved by resolvin treatment [references]
D-series	RvD1	Mouse	CFA	Mechanical allodynia, heat hyperalgesia [35, 36], mechanical hyperalgesia [36]
			Carrageenan	Chemical pain [36]
			Formalin	Phase 1 and 2 inflammatory pain [35, 36]
			Prostaglandin E2	Acute mechanical pain [36]
			TRP agonists	Acute chemical pain [36]
			Incision	Mechanical allodynia [35]
		Rat	Incision	Mechanical allodynia and hyperalgesia [37]
			Trinitrobenzene sulfonic acid-induced chronic pancreatitis	Mechanical allodynia [38]
	RvD2	Mouse	CFA; Carrageenan	Mechanical allodynia and heat hyperalgesia [34]
			Formalin	Phase 2 inflammatory pain [34]
	AT-RvD1	Mouse	CFA	Heat hyperalgesia [39]
			Carrageenan	Chemical pain [39]
			TRP agonists	Heat hypersensitivity [39]
		Rat	Carrageenan	Mechanical allodynia [40]
E-series	RvE1	Mouse	CFA; Carrageenan; Intrathecal TNF-α	Mechanical allodynia and heat hyperalgesia [35]
			Formalin	Phase 1 and 2 inflammatory pain [35]
			TRP agonists	Acute capsaicin-evoked pain [35]
			Spinal nerve ligation	Heat hyperalgesia [35]
			Chronic constriction injury	Mechanical allodynia and heat hyperalgesia [41]
Others	NPD1	Mouse	CFA	Heat hyperalgesia [28]
			Formalin	Phase 2 inflammatory pain [28]
			TNF-	Mechanical allodynia and heat hyperalgesia [28]
			TRP agonists	Acute capsaicin-evoked pain [28]
	Maresin 1	Mouse	TRP agonists	Acute capsaicin-evoked pain [32]
			Vincristine chemotherapy	Mechanical allodynia [32]