The Roads to Mitochondrial Dysfunction in a Rat Model of Posttraumatic Syringomyelia

Figure 8

Ultrastructural time course of cellular changes associated with quisqualic acid excitotoxicity in the motoneuron of the spinal cord: NMDA receptor-mediated excitotoxicity resembles necrosis, and cellular changes induced by laminectomy in the motoneuron of the spinal cord: apoptosis. Electron micrographs illustrate motoneuronal changes associated with the necrotic-like degenerative neuronal morphology induced by quisqualic acid ((c), (e), (g)). A normal motoneuron from the spinal cord is shown for comparison in (a). Selected motoneurons displaying the predominant morphological changes at the different times after quisqualic acid injection (1 h, 24 h, and 6 weeks) were arranged in a temporal sequence to show the progression of excitotoxic injury ((c), (e), (g)), apoptotic changes in the laminectomy group were shown at corresponding time points ((b), (d), (f)). Refer to Section 3 for a description of nuclear changes.

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