MicroRNAs: Novel Players in Aortic Aneurysm

Table 2

Use of some miRNAs in the treatment of aortic aneurysm (AA).

miRNA	Model	Target	Anti-miR/mimics	Effects	Year/author
miR-21	Mice; AngII-AAA; PPE-AAA	PTEN	Mimics	Induces VSMC proliferation, decreases apoptosis via PTEN/PI3K/AKT, and prevents AA	2012 Maegdefessel et al. [49]
miR-24	Mice; AngII-AAA; PPE-AAA	CHI3L1	Mimics	Limits aortic vascular inflammation and AA formation	2014 Maegdefessel et al. [15]
miR-29	Aged mice; AngII-AAA	Col1A1, Col3A1,; elastin,; Mcl-1	Antagomir, LNA-anti-miR	Induces ECM expression and inhibits AA formation	2011 Boon et al. [56]
miR-29b	Mice; AngII-AAA; PPE-AAA	Col1A1, Col3A1,; elastin,; Mcl-1	Antagomir, LNA-anti-miR	Increases collagen expression, leading to an early fibrotic response in the abdominal aortic wall, and prevents AAA progression	2012 Maegdefessel et al. [57]
miR-29b	Marfan mice; Fbn1^C1039G/+; AA	Col1A1, Col3A1,; elastin,; Mcl-1	Antagomir, LNA-anti-miR	Reduces ECM deposition and VSMC apoptosis and prevents AA formation	2012 Merk et al. [58]
miR-195	Mice; AngII-AAA	Col1A1, Col3A1,; elastin,; Mcl-1	Antagomir, LNA-anti-miR	Reduces ECM deposition and VSMC apoptosis and prevents AA formation	2014 Zampetaki et al. [59]
miR-712/miR-205	Mice; AngII-AAA	TIMP3, RECK	Antagomir, LNA-anti-miR	Inhibits both endothelial and circulating leukocyte inflammation; Decreases MMPs activity and inflammation; Prevents AAA formation	2014 Kim et al. [32]

AngII: angiotensin II, PPE: porcine pancreatic elastase, AAA: abdominal aortic aneurysm, LNA: alpha-linolenic acid, VSMC: vascular smooth muscle cell, ECM: extracellular matrix, and MMPs: matrix metalloproteinases.