Deep Response in Multiple Myeloma: A Critical Review

Table 1

Definition of response according to the last classification of the IMF.

Categories of response according to IMF 2011	Level of detection
PR	MC < 50%
VGPR	MC < 90%
nCR	MC 0.1–0.5 g/dl (EF−/IF+)
CR	MC ≤ 0,5 g/dl (IF−)
	PC in BM < 5%
Stringent CR	sFLC ratio +BM ICH
Immunophenotypic CR	sCR+ nonaberrant PC in 1,000,000 cells
Molecular CR	CR+ nonclonal plasma cells with sensitivity > 10^−5