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BioMed Research International
Volume 2015, Article ID 832863, 5 pages
Research Article

Comparison of Macular Thickness in Patients with Keratoconus and Control Subjects Using the Cirrus HD-OCT

1Unit of Optometry, Department of Clinical Neuroscience, Karolinska Institutet, P.O. Box 8056, 10420 Stockholm, Sweden
2Optics Department, University of Valencia, C/Dr. Moliner 50, 46100 Burjassot, Spain
3TERTC, University of Houston, College of Optometry, Houston, TX 77204-2020, USA

Received 8 September 2014; Revised 19 December 2014; Accepted 6 February 2015

Academic Editor: Michele Figus

Copyright © 2015 R. L. Brautaset et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. The aim of the present study was to compare macular thickness in patients with keratoconus (KC) with macular thickness in healthy subjects. Subjects and Methods. Twenty-six patients with KC and 52 control subjects were included. The macular structure was evaluated using a Zeiss Cirrus HD-OCT. The scan pattern used was 512 × 128, which covers an area of approximately 6 × 6 mm of the retina. The cube volume was assessed as well as macular thickness in each of the 9 sectors defined by the software. Results. The mean signal strength was significantly lower in the KC group (mean 8.4, range 6–10) compared with the control group (mean 9.7, range 7–10), (unpaired -test). There were no significant differences in cube volume (unpaired -test), cube average thickness, or macular thickness between the KC group and the control subjects in any of the retinal locations (one-way ANOVA). Conclusion. Macular structure as measured by OCT in KC subjects should be expected to lie within the range of age and sex matched controls.