Review Article

The Sea Lamprey as an Etiological Model for Biliary Atresia

Figure 2

Liver morphology at metamorphic stages 1 ((a) and (b)) and 2 ((c) and (d)). (a) Heavy fibrosis (red stain) around proliferating bile ducts (black arrows) and activated macrophages (yellow cells with filopodia) clearing the fibrosis and dead cell debris. (b) Cholangiocyte proliferation and autolysis (asterisks). (c) Lymphocyte infiltration at hepatocyte loci (white arrow). (d) Heavy fibrosis (red stain) containing dead cells and fibrotic debris (black). Paraffin sections were stained with Picro Sirius Red (Gladstone). Scale bar: 50 μm.
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