Verification of the Chromosome Region 9q21 Association with Pelvic Organ Prolapse Using RegulomeDB Annotations

Table 3

The distribution of rs12237222 genotypes among cases and controls.

Genotypes	Control		POP		Crude P value,; OR (95% CI)	Adjusted P value^aOR, (95% CI)
	Number (%)	HWP	Number (%)	HWP
rs12237222
T/T	104 (35.7)	0.63	55 (26.2)	0.21	0.023 (dom); 1.57 (1.06–2.31)	0.12 (dom); 1.41 (0.91–2.18)
T/G	136 (46.7)		114 (54.3)
G/G	51 (17.5)		41 (19.5)

HWP: Hardy-Weinberg probability; OR: odds ratio; CI: confidence interval; dom: dominant model.
^aAdjusted by age, body mass index (BMI), perineal trauma in childbirth, and vaginal parity. In multivariate analysis, there were 271 controls and 198 cases.