Verification of the Chromosome Region 9q21 Association with Pelvic Organ Prolapse Using RegulomeDB Annotations
Table 4
The distribution of 9q21 haplotypes among cases and controls.
Number
rs4077632
rs2807303
rs2777781
rs11139451
rs12237222
rs12551710
Frequencies
value
OR (95% CI)
Controls
POP
Six SNP-haplotype associations with response
1
A
T
A
T
T
C
0.1334
0.0985
—
1.00
2
A
C
A
T
T
C
0.1185
0.0943
0.38
0.59 (0.19–1.90)
3
G
C
A
T
G
C
0.0436
0.0937
0.24
1.92 (0.65–5.71)
4
A
C
A
T
G
C
0.059
0.1019
0.029
3.36 (1.13–9.95)
Five SNP-haplotype associations with response
1
A
C
A
T
—
C
0.1807
0.205
—
1.00
2
A
T
A
T
—
C
0.1662
0.1324
0.96
1.02 (0.48–2.16)
3
G
C
A
T
—
C
0.1146
0.1171
0.68
0.85 (0.39–1.86)
4
A
C
T
T
—
C
0.0949
0.0763
0.63
0.81 (0.34–1.92)
Two SNP-haplotype associations with response
1
—
—
A
—
T
—
0.4581
0.3663
—
1.00
2
—
—
A
—
G
—
0.2782
0.3575
0.0091
1.72 (1.15–2.59)
3
—
—
T
—
T
—
0.1328
0.167
0.064
1.62 (0.97–2.70)
4
—
—
T
—
G
—
0.1309
0.1092
0.63
0.88 (0.53–1.47)
Only haplotypes with total frequencies ≥10% are considered. Analysis is adjusted by age, body mass index (BMI), peritoneal trauma in childbirth, and vaginal parity. Significant results are in bold.
