Research Article

Clinical Significance of Cannabinoid Receptors CB1 and CB2 Expression in Human Malignant and Benign Thyroid Lesions

Table 2

Associations of CB1 and CB2 expression with clinicopathological characteristics in 44 patients with malignant thyroid lesions.

Clinicopathological characteristicsCB1 expressionCB2 expression
LowHigh valueLowHigh value

21 (48%)23 (52%)20 (45%)24 (55%)
Age (mean SD; yrs)0.7201
Gender0.20210.9456
 Female15 (34%)20 (45%)16 (36%)19 (43%)
 Male6 (14%)3 (7%)4 (9%)5 (12%)
Tumor size (T)0.60110.4844
 T115 (34%)18 (41%)16 (36%)17 (39%)
 T2–46 (14%)5 (11%)4 (9%)7 (16%)
Lymph node metastasis (N)0.71320.0301
 N019 (43%)20 (45%)20 (45%)19 (43%)
 N12 (5%)3 (7%)0 (0%)5 (12%)
Capsular invasion0.82500.1165
 No 17 (39%)18 (41%)18 (41%)17 (39%)
 Yes4 (9%)5 (11%)2 (4%)7 (16%)
Lymphatic invasion0.52200.1989
 No18 (41%)18 (41%)18 (41%)18 (41%)
 Yes3 (7%)5 (11%)2 (4%)6 (14%)
Vascular invasion0.33980.0555
 No 20 (45%)20 (45%)20 (45%)20 (45%)
 Yes1 (3%)3 (7%)0 (0%)4 (10%)
Ki-67 protein statement0.58270.2828
 Below mean value12 (27%)15 (34%)14 (32%)13 (30%)
 Over mean value9 (21%)8 (18%)6 (14%)11 (25%)