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BioMed Research International
Volume 2015, Article ID 839820, 5 pages
Clinical Study

Acute Cardioembolic and Thrombotic Middle Cerebral Artery Occlusions Have Different Morphological Susceptibility Signs on T2-Weighted Magnetic Resonance Images

Department of Neurology, Peking University Third Hospital, Beijing 100191, China

Received 31 July 2015; Revised 9 September 2015; Accepted 20 September 2015

Academic Editor: Sung-Chun Tang

Copyright © 2015 Mei Zheng and Dong-sheng Fan. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Presence of susceptibility sign on middle cerebral artery (MCA) in -weighted magnetic resonance (MR) images has been reported to detect acute MCA thromboembolic occlusion. However, the pathophysiologic course of thrombotic MCA occlusion differs from embolic occlusion, which might induce different imaging characters. Our study found that the occurrence rate of the MCA susceptibility sign in cardioembolism (CE) patients was significantly higher than in large artery atherosclerosis (LAA) patients, and the diameter of the MCA susceptibility sign for CE was greater than for LAA. Moreover, the patients with hemorrhagic transformation had MCA susceptibility signs with a significant larger mean diameter than patients without hemorrhagic transformation. Therefore, we hypothesized that the morphology of susceptibility signs could be used to differentiate acute cardioembolic and thrombotic MCA occlusions, which helped to select appropriate treatment strategies for different patients.