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BioMed Research International
Volume 2015, Article ID 840542, 26 pages
Review Article

Novel Investigations of Flavonoids as Chemopreventive Agents for Hepatocellular Carcinoma

1Department of Internal Medicine, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan
2Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, No. 325, Section 2, Cheng-Kung Road, Neihu, Taipei 114, Taiwan
3Department of Pathology, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan
4Department of General Surgery, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan

Received 2 September 2015; Accepted 19 October 2015

Academic Editor: Javier G. Gallego

Copyright © 2015 Chen-Yi Liao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We would like to highlight the application of natural products to hepatocellular carcinoma (HCC). We will focus on the natural products known as flavonoids, which target this disease at different stages of hepatocarcinogenesis. In spite of the use of chemotherapy and radiotherapy in treating HCC, patients with HCC still face poor prognosis because of the nature of multidrug resistance and toxicity derived from chemotherapy and radiotherapy. Flavonoids can be found in many vegetables, fruits, and herbal medicines that exert their different anticancer effects via different intracellular signaling pathways and serve as antioxidants. In this review, we will discuss seven common flavonoids that exert different biological effects against HCC via different pathways.