Identification of Gene and MicroRNA Signatures for Oral Cancer Developed from Oral Leukoplakia

Table 1

The modules we identified to be associated with oral cancer, and the enriched functions and pathways of the proteins from these modules.

	Genes in module (DEGs were in bold)	Top 10 enriched biological processes	Top 10 enriched KEGG pathways
Module 1	DPM3 DPM1 DPM2	GO: 0032870 cellular response to hormone stimulus	hsa05220: Chronic myeloid leukemia
Module 2	HIRA HIST2H2BE HIRIP3
Module 3	EGFR PDGFRB PTPN11 SHC1 SRC STAT5A STAT5B CBL	GO: 0007169 transmembrane receptor protein tyrosine kinase signaling pathway	hsa05200: Pathways in cancer
Module 4	CSNK2A1 NCL TOP1 TP53
Module 5	NR3C1 POU2F1 RARA STAT5A STAT5B NCOR2	GO: 0009725 response to hormone stimulus	hsa04062: Chemokine signaling pathway
Module 6	LRP1 SKIL SNX17	GO: 0007167 enzyme linked receptor protein signaling pathway	hsa05210: Colorectal cancer
Module 7	GNB2 GNG4 RAF1
Module 8	EGFR INSR LEPR PDGFRA PDGFRB SNX6 SNX1 SNX2 SNX4 ACVR1B ACVR2B	GO: 0009719 response to endogenous stimulus	hsa04012: ErbB signaling pathway
Module 9	EGFR JAK2 PDGFRB PTPN2 PTPN11 SRC STAT1 STAT3 STAT5A STAT5B	GO: 0010033 response to organic substance	hsa05214: Glioma
Module 10	SIRT1 HEY2 HES1	GO: 0007166 cell surface receptor linked signal transduction	hsa05212: Pancreatic cancer
Module 11	WNT4 SFRP1 FZD6
Module 12	PABPC1 HNRNPD PCBP1 PCBP2	GO: 0006468 protein amino acid phosphorylation	hsa05221: Acute myeloid leukemia
Module 13	PRKACA RAF1 RAP1A BRAF
		GO: 0018108 peptidyl-tyrosine phosphorylation	hsa04630: Jak-STAT signaling pathway
		GO: 0018212 peptidyl-tyrosine modification	hsa05218: Melanoma