Identification of Gene and MicroRNA Signatures for Oral Cancer Developed from Oral Leukoplakia

Table 4

The miRNA regulators of modules and their target genes.

miRNA (in bold if the expression of miRNA and that of its target gene is negatively correlated)	miRNA Expression change direction	miRNA target gene	Gene Expression change direction
hsa-miR-499-5p	Up	TOP1	up
hsa-miR-549	Up	TOP1	up
hsa-miR-205	Up	LRP1	down
hsa-miR-525-5p	down	WNT4	down
hsa-miR-21	Up	PCBP1; PCBP2	down; down
hsa-miR-323-3p	down	PCBP1; PCBP2	down; down
hsa-miR-423-3p	down	PABPC1	up
hsa-miR-491-3p	Up	RAP1A	down