Genetic Polymorphism in Extracellular Regulators of Wnt Signaling Pathway

Table 1

SNPs in the selected genes and associated clinical phenotypes.

Gene	Chromosome	SNP ID	Geographical cohort	Phenotype	Reference
SOST; DC1	7p21.1	rs16878759; rs12699800; rs17619769	China	Osteoporosis	[23]
SOST	17q21.3	rs851054 rs851056	Australia	BMD and BMC at total hip	[18]
SOST	17q21.3	rs1513670; rs7220711; rs1107748	Iceland, Denmark, and Australia	Hip BMD associated	[30]
SOST	17q21.3	rs1230399	China	Spine, FN, trochanter, and total hip BMD	[31]
sFRP3	2q32.1	rs288326; rs7775	Caucasian, Spanish	Knee osteoarthritis, hip osteoarthritis	[32–34]
sFRP3	2q32.1	rs7775	Saudi	Breast cancer	[35]
DKK1	10q21	rs1569198	Caucasian	Hip axis length	[36]
DKK3	11p15.3	rs6485350	Saudi	Breast cancer	[35]
DKK3	11p15.3	rs1472189	Japan	Renal cancer	[37]
DKK4	8p11.1	rs3763511	Saudi	Breast cancer	[35]