Modulation of MicroRNAs by Phytochemicals in Cancer: Underlying Mechanisms and Translational Significance

Table 1

Phytochemical-mediated regulation of miRNAs in cancer. Modulation of miRNA expression by certain phytochemical agents and effect on cancer pathobiology.

Phytochemical	miRNA	Function	Reference
Resveratrol	miR-141, miR-663, and miR-200c	Invasiveness, EMT, and metastasis	[57–61, 114]
	miR-17, miR-21, miR-25, miR-92a-2, miR-103-1, and miR-103-2
EGCG	miR-16, miR-210, miR-7-1, miR-34a, and miR-99a	Apoptosis	[62–66]
	miR-21, miR-98-5p, miR-92, miR-93, and miR-106b	Proliferation, anchorage-independent growth, and drug resistance
Genistein	miR-16	Apoptosis	[67, 68]
	miR-221 and miR-222	Growth
Curcumin	miR-15a, miR-16, and miR-186^*	Apoptosis	[80, 82, 83]
	miR-21	Metastasis
Quercetin	let-7	Growth; Apoptosis	[88, 89]
	miR-27a
Camptothecin	miR-125b	Apoptosis	[92]
DIM	miR-21, miR-200b, miR-200c, let-7b, let-7c, let-7d, let-7e, and miR-146a	Growth, EMT, drug resistance, invasion, and metastasis	[95–97]