Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2015, Article ID 851320, 7 pages
http://dx.doi.org/10.1155/2015/851320
Research Article

Potentially Functional Polymorphisms in POU5F1 Gene Are Associated with the Risk of Lung Cancer in Han Chinese

Department of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing 211166, China

Received 10 September 2015; Revised 28 November 2015; Accepted 6 December 2015

Academic Editor: Robert A. Vierkant

Copyright © 2015 Rui Niu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. M. Parkin, P. Pisani, A. D. Lopez, and E. Masuyer, “At least one in seven cases of cancer is caused by smoking. Global estimates for 1985,” International Journal of Cancer, vol. 59, no. 4, pp. 494–504, 1994. View at Publisher · View at Google Scholar · View at Scopus
  2. C. D. Berg, D. R. Aberle, and D. E. Wood, “Lung cancer screening: promise and pitfalls,” American Society of Clinical Oncology Educational Book, pp. 450–457, 2012. View at Google Scholar
  3. C. I. Amos, X. Wu, P. Broderick et al., “Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1,” Nature Genetics, vol. 40, no. 5, pp. 616–622, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. P. Broderick, Y. Wang, J. Vijayakrishnan et al., “Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study,” Cancer Research, vol. 69, no. 16, pp. 6633–6641, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. J. Dong, Z. Hu, C. Wu et al., “Association analyses identify multiple new lung cancer susceptibility loci and their interactions with smoking in the Chinese population,” Nature Genetics, vol. 44, no. 8, pp. 895–899, 2012. View at Publisher · View at Google Scholar
  6. Z. Hu, C. Wu, Y. Shi et al., “A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese,” Nature Genetics, vol. 43, no. 8, pp. 792–796, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. R. J. Hung, J. D. McKay, V. Gaborieau et al., “A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25,” Nature, vol. 452, no. 7187, pp. 633–637, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. Q. Lan, C. A. Hsiung, K. Matsuo et al., “Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia,” Nature Genetics, vol. 44, pp. 1330–1335, 2012. View at Google Scholar
  9. J. D. McKay, R. J. Hung, V. Gaborieau et al., “Lung cancer susceptibility locus at 5p15.33,” Nature Genetics, vol. 40, no. 12, pp. 1404–1406, 2008. View at Publisher · View at Google Scholar
  10. K. Shiraishi, H. Kunitoh, Y. Daigo et al., “A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population,” Nature Genetics, vol. 44, no. 8, pp. 900–903, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. Y. Wang, P. Broderick, E. Webb et al., “Common 5p15.33 and 6p21.33 variants influence lung cancer risk,” Nature Genetics, vol. 40, no. 12, pp. 1407–1409, 2008. View at Publisher · View at Google Scholar · View at Scopus
  12. Y. Babaie, R. Herwig, B. Greber et al., “Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells,” STEM CELLS, vol. 25, no. 2, pp. 500–510, 2007. View at Publisher · View at Google Scholar · View at Scopus
  13. H. R. Schöler, S. Ruppert, N. Suzuki, K. Chowdhury, and P. Gruss, “New type of POU domain in germ line-specific protein Oct-4,” Nature, vol. 344, no. 6265, pp. 435–439, 1990. View at Publisher · View at Google Scholar · View at Scopus
  14. K. Okamoto, H. Okazawa, A. Okuda, M. Sakai, M. Muramatsu, and H. Hamada, “A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells,” Cell, vol. 60, no. 3, pp. 461–472, 1990. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Pesce and H. R. Schöler, “Oct-4: gatekeeper in the beginnings of mammalian development,” Stem Cells, vol. 19, no. 4, pp. 271–278, 2001. View at Publisher · View at Google Scholar · View at Scopus
  16. M. H. Rosner, M. A. Vigano, K. Ozato et al., “A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo,” Nature, vol. 345, no. 6277, pp. 686–692, 1990. View at Publisher · View at Google Scholar · View at Scopus
  17. M. Monk and C. Holding, “Human embryonic genes re-expressed in cancer cells,” Oncogene, vol. 20, no. 56, pp. 8085–8091, 2001. View at Publisher · View at Google Scholar · View at Scopus
  18. M.-H. Tai, C.-C. Chang, L. K. Olson, and J. E. Trosko, “Oct4 expression in adult human stem cells: evidence in support of the stem cell theory of carcinogenesis,” Carcinogenesis, vol. 26, no. 2, pp. 495–502, 2005. View at Publisher · View at Google Scholar · View at Scopus
  19. J. E. Visvader and G. J. Lindeman, “Cancer stem cells in solid tumours: accumulating evidence and unresolved questions,” Nature Reviews Cancer, vol. 8, no. 10, pp. 755–768, 2008. View at Publisher · View at Google Scholar · View at Scopus
  20. U. R. Rapp, F. Ceteci, and R. Schreck, “Oncogene-induced plasticity and cancer stem cells,” Cell Cycle, vol. 7, no. 1, pp. 45–51, 2008. View at Publisher · View at Google Scholar · View at Scopus
  21. S. Amini, F. Fathi, J. Mobalegi, H. Sofimajidpour, and T. Ghadimi, “The expressions of stem cell markers: Oct4, Nanog, Sox2, nucleostemin, Bmi, Zfx, Tcl1, Tbx3, Dppa4, and Esrrb in bladder, colon, and prostate cancer, and certain cancer cell lines,” Anatomy & Cell Biology, vol. 47, no. 1, pp. 1–11, 2014. View at Publisher · View at Google Scholar
  22. S. Gidekel, G. Pizov, Y. Bergman, and E. Pikarsky, “Oct-3/4 is a dose-dependent oncogenic fate determinant,” Cancer Cell, vol. 4, no. 5, pp. 361–370, 2003. View at Publisher · View at Google Scholar · View at Scopus
  23. C.-C. Chang, G.-S. Shieh, P. Wu, C.-C. Lin, A.-L. Shiau, and C.-L. Wu, “Oct-3/4 expression reflects tumor progression and regulates motility of bladder cancer cells,” Cancer Research, vol. 68, no. 15, pp. 6281–6291, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. G. Karoubi, L. Cortes-Dericks, M. Gugger, D. Galetta, L. Spaggiari, and R. A. Schmid, “Atypical expression and distribution of embryonic stem cell marker, OCT4, in human lung adenocarcinoma,” Journal of Surgical Oncology, vol. 102, no. 6, pp. 689–698, 2010. View at Publisher · View at Google Scholar · View at Scopus
  25. L. Shen, M. Du, C. Wang et al., “Clinical Significance of POU5F1P1 rs10505477 polymorphism in Chinese gastric cancer patients receving cisplatin-based chemotherapy after surgical resection,” International Journal of Molecular Sciences, vol. 15, no. 7, pp. 12764–12777, 2014. View at Publisher · View at Google Scholar · View at Scopus
  26. M. M. Finucane, G. A. Stevens, M. J. Cowan et al., “National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9.1 million participants,” The Lancet, vol. 377, no. 9765, pp. 557–567, 2011. View at Publisher · View at Google Scholar · View at Scopus
  27. H. Iida, M. Suzuki, R. Goitsuka, and H. Ueno, “Hypoxia induces CD133 expression in human lung cancer cells by up-regulation of OCT3/4 and SOX2,” International Journal of Oncology, vol. 40, no. 1, pp. 71–79, 2012. View at Publisher · View at Google Scholar · View at Scopus
  28. S.-H. Chiou, M.-L. Wang, Y.-T. Chou et al., “Coexpression of Oct4 and Nanog enhances malignancy in lung adenocarcinoma by inducing cancer stem cell-like properties and epithelial-mesenchymal transdifferentiation,” Cancer Research, vol. 70, no. 24, pp. 10433–10444, 2010. View at Publisher · View at Google Scholar · View at Scopus
  29. C. Xu, D. Xie, S.-C. Yu et al., “β-catenin/POU5F1/SOX2 transcription factor complex mediates IGF-I receptor signaling and predicts poor prognosis in lung adenocarcinoma,” Cancer Research, vol. 73, no. 10, pp. 3181–3189, 2013. View at Publisher · View at Google Scholar · View at Scopus
  30. Z. Chen, T. Wang, L. Cai et al., “Clinicopathological significance of non-small cell lung cancer with high prevalence of Oct-4 tumor cells,” Journal of Experimental and Clinical Cancer Research, vol. 31, article 10, 2012. View at Publisher · View at Google Scholar · View at Scopus
  31. R. K. Olsen, S. Broner, R. Sabaratnam et al., “The ETFDH c.158A>G variation disrupts the balanced interplay of ESE- and ESS-binding proteins thereby causing missplicing and multiple Acyl-CoA dehydrogenation deficiency,” Human Mutation, vol. 35, pp. 86–95, 2014. View at Google Scholar
  32. A. Nishida, N. Kataoka, Y. Takeshima et al., “Chemical treatment enhances skipping of a mutated exon in the dystrophin gene,” Nature Communications, vol. 2, no. 1, article 308, 2011. View at Publisher · View at Google Scholar · View at Scopus
  33. S. Sen, I. Talukdar, and N. J. G. Webster, “SRp20 and CUG-BP1 modulate insulin receptor exon 11 alternative splicing,” Molecular and Cellular Biology, vol. 29, no. 3, pp. 871–880, 2009. View at Publisher · View at Google Scholar · View at Scopus
  34. B. J. Blencowe, “Exonic splicing enhancers: mechanism of action, diversity and role in human genetic diseases,” Trends in Biochemical Sciences, vol. 25, no. 3, pp. 106–110, 2000. View at Publisher · View at Google Scholar · View at Scopus
  35. J. Song, H. Murakami, H. Tsutsui et al., “Genomic organization and expression of a human gene for Myc-associated zinc finger protein (MAZ),” The Journal of Biological Chemistry, vol. 273, no. 32, pp. 20603–20614, 1998. View at Publisher · View at Google Scholar · View at Scopus
  36. L. Jiao, Y. Li, D. Shen et al., “The prostate cancer-up-regulated myc-associated zinc-finger protein (MAZ) modulates proliferation and metastasis through reciprocal regulation of androgen receptor,” Medical Oncology, vol. 30, no. 2, article 570, 2013. View at Publisher · View at Google Scholar · View at Scopus
  37. L. C. Murphy, N. Huzel, and J. R. Davie, “Novel DNase I hypersensitive sites in the 3′-flanking region of the human c-myc gene,” DNA and Cell Biology, vol. 15, no. 7, pp. 543–548, 1996. View at Google Scholar