Environmental Lead Exposure, Catalase Gene, and Markers of Antioxidant and Oxidative Stress Relation to Hypertension: An Analysis Based on the EGAT Study

Table 3

Biochemical tests, blood lead, and determinants of antioxidant and oxidative stress, classified by CAT genotypes among three groups.

		Normotension		Prehypertension				Hypertension
	CC; ( = 104)	CT; ( = 145)	TT; ( = 83)	CC; ( = 139)	CT; ( = 207)	TT; ( = 86)	CC; ( = 73)	CT; ( = 104)	TT; ( = 45)
Biochemical tests
Triglyceride, mg/dL	135.0 ± 7.7	129.6 ± 6.2	135.5 ± 7.1	161.0 ± 8.9	166.7 ± 8.1	171.0 ± 11.7	166.8 ± 9.8	206.9 ± 14.9	195.9 ± 20.7
HDL cholesterol, mg/dL	49.36 ± 1.04	49.91 ± 0.87	49.25 ± 1.14	50.37 ± 0.93	49.56 ± 0.66	48.91 ± 1.16	50.83 ± 1.32	48.70 ± 1.01	48.32 ± 1.48
LDL cholesterol, mg/dL	149.4 ± 4.2	156.1 ± 3.2	149.21 ± 3.6	149.3 ± 2.9	148.1 ± 2.9	147.1 ± 4.4	151.1 ± 4.9	145.5 ± 4.1	141.9 ± 5.3
Total cholesterol, mg/dL	225.8 ± 4.6	232.0 ± 3.4	225.7 ± 4.0	232.4 ± 3.3	229.2 ± 3.2	229.8 ± 4.7	235.1 ± 5.1	234.2 ± 4.3	226.9 ± 4.6
Fasting glucose, mg/dL	102.2 ± 2.9	99.94 ± 2.06	99.91 ± 1.76	105.4 ± 2.1	106.1 ± 1.9	106.4 ± 2.6	104.6 ± 2.1	119. ± 5.9	109.1 ± 5.5
Creatinine, mg/dL	1.10 ± 0.01	1.11 ± 0.01	1.08 ± 0.01	1.11 ± 0.01	1.15 ± 0.01	1.15 ± 0.02	1.15 ± 0.02	1.13 ± 0.02	1.14 ± 0.02
Uric acid, mg/dL	5.95 ± 0.12	5.94 ± 0.09	6.03 ± 0.13	6.51 ± 0.09	6.31 ± 0.09	6.46 ± 0.14	6.57 ± 0.13	6.60 ± 0.13	6.72 ± 0.19
Blood lead, g/dL	4.32± 0.17	4.51 ± 0.16	4.36 ± 0.21	4.71 ± 0.16	4.42 ± 0.14	4.59 ± 0.21	5.32 ± 0.31	5.38 ± 0.22	6.06 ± 0.41^a
Antioxidant determinants
CAT, U/gHb	32341 ± 1017	29717 ± 766^a	27423 ± 1129^a,b	29621 ± 563	28014 ± 425	26741 ± 498^a	28745 ± 765	28012 ± 568	26104 ± 925^a
SOD, U/gHb	2301 ± 133	2571 ± 136	2295 ± 135	2286 ± 114	2436 ± 107	2321 ± 161	2055 ± 151	2469 ± 131	2616 ± 265^a
GPx, U/gHb	34.31 ± 1.63	36.19 ± 1.33	32.03 ± 1.42	36.05 ± 1.41	34.58 ± 1.14	33.91 ± 1.74	37.65 ± 1.87	34.51 ± 1.59	37.32 ± 2.97
GSH, mg/dL	31.16 ± 0.62	32.05 ± 0.49	30.64 ± 0.73	31.46 ± 0.55	31.76 ± 0.48	30.50 ± 0.64	30.75 ± 0.69	30.97 ± 0.70	33.17 ± 1.12
Oxidative stress determinant
MDA, mol/L	7.95 ± 0.54	8.71 ± 0.59	7.76 ± 0.64	8.32 ± 0.49	7.88 ± 0.35	7.86 ± 0.60	8.31 ± 0.65	9.75 ± 0.73^a	9.67 ± 0.88^a

AM ± SE, GM ± SE.
Significantly different from individuals with CC and CT, respectively, .