Environmental Lead Exposure, Catalase Gene, and Markers of Antioxidant and Oxidative Stress Relation to Hypertension: An Analysis Based on the EGAT Study
Table 3
Biochemical tests, blood lead, and determinants of antioxidant and oxidative stress, classified by CAT genotypes among three groups.
Normotension
Prehypertension
Hypertension
CC ( = 104)
CT ( = 145)
TT ( = 83)
CC ( = 139)
CT ( = 207)
TT ( = 86)
CC ( = 73)
CT ( = 104)
TT ( = 45)
Biochemical tests
Triglyceride, mg/dL
135.0 ± 7.7
129.6 ± 6.2
135.5 ± 7.1
161.0 ± 8.9
166.7 ± 8.1
171.0 ± 11.7
166.8 ± 9.8
206.9 ± 14.9
195.9 ± 20.7
HDL cholesterol, mg/dL
49.36 ± 1.04
49.91 ± 0.87
49.25 ± 1.14
50.37 ± 0.93
49.56 ± 0.66
48.91 ± 1.16
50.83 ± 1.32
48.70 ± 1.01
48.32 ± 1.48
LDL cholesterol, mg/dL
149.4 ± 4.2
156.1 ± 3.2
149.21 ± 3.6
149.3 ± 2.9
148.1 ± 2.9
147.1 ± 4.4
151.1 ± 4.9
145.5 ± 4.1
141.9 ± 5.3
Total cholesterol, mg/dL
225.8 ± 4.6
232.0 ± 3.4
225.7 ± 4.0
232.4 ± 3.3
229.2 ± 3.2
229.8 ± 4.7
235.1 ± 5.1
234.2 ± 4.3
226.9 ± 4.6
Fasting glucose, mg/dL
102.2 ± 2.9
99.94 ± 2.06
99.91 ± 1.76
105.4 ± 2.1
106.1 ± 1.9
106.4 ± 2.6
104.6 ± 2.1
119. ± 5.9
109.1 ± 5.5
Creatinine, mg/dL
1.10 ± 0.01
1.11 ± 0.01
1.08 ± 0.01
1.11 ± 0.01
1.15 ± 0.01
1.15 ± 0.02
1.15 ± 0.02
1.13 ± 0.02
1.14 ± 0.02
Uric acid, mg/dL
5.95 ± 0.12
5.94 ± 0.09
6.03 ± 0.13
6.51 ± 0.09
6.31 ± 0.09
6.46 ± 0.14
6.57 ± 0.13
6.60 ± 0.13
6.72 ± 0.19
Blood lead, g/dL
4.32± 0.17
4.51 ± 0.16
4.36 ± 0.21
4.71 ± 0.16
4.42 ± 0.14
4.59 ± 0.21
5.32 ± 0.31
5.38 ± 0.22
6.06 ± 0.41a
Antioxidant determinants
CAT, U/gHb
32341 ± 1017
29717 ± 766a
27423 ± 1129a,b
29621 ± 563
28014 ± 425
26741 ± 498a
28745 ± 765
28012 ± 568
26104 ± 925a
SOD, U/gHb
2301 ± 133
2571 ± 136
2295 ± 135
2286 ± 114
2436 ± 107
2321 ± 161
2055 ± 151
2469 ± 131
2616 ± 265a
GPx, U/gHb
34.31 ± 1.63
36.19 ± 1.33
32.03 ± 1.42
36.05 ± 1.41
34.58 ± 1.14
33.91 ± 1.74
37.65 ± 1.87
34.51 ± 1.59
37.32 ± 2.97
GSH, mg/dL
31.16 ± 0.62
32.05 ± 0.49
30.64 ± 0.73
31.46 ± 0.55
31.76 ± 0.48
30.50 ± 0.64
30.75 ± 0.69
30.97 ± 0.70
33.17 ± 1.12
Oxidative stress determinant
MDA, mol/L
7.95 ± 0.54
8.71 ± 0.59
7.76 ± 0.64
8.32 ± 0.49
7.88 ± 0.35
7.86 ± 0.60
8.31 ± 0.65
9.75 ± 0.73a
9.67 ± 0.88a
AM ± SE, GM ± SE. Significantly different from individuals with CC and CT, respectively, .