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BioMed Research International
Volume 2015, Article ID 856859, 7 pages
http://dx.doi.org/10.1155/2015/856859
Research Article

Delivery of Antibiotics from Cementless Titanium-Alloy Cubes May Be a Novel Way to Control Postoperative Infections

1Department of Industrial Engineering, University of Stellenbosch, Stellenbosch 7600, South Africa
2Department of Microbiology, University of Stellenbosch, Stellenbosch 7600, South Africa

Received 13 January 2015; Accepted 27 February 2015

Academic Editor: Konstantinos Anagnostakos

Copyright © 2015 Martin B. Bezuidenhout et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. M. Kurtz, E. Lau, J. Schmier, K. L. Ong, K. Zhao, and J. Parvizi, “Infection burden for hip and knee arthroplasty in the United States,” The Journal of Arthroplasty, vol. 23, no. 7, pp. 984–991, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. J. Lange, A. Troelsen, R. W. Thomsen, and K. Søballe, “Chronic infections in hip arthroplasties: comparing risk of reinfection following one-stage and two-stage revision: a systematic review and meta-analysis,” Clinical Epidemiology, vol. 4, no. 1, pp. 57–73, 2012. View at Publisher · View at Google Scholar · View at Scopus
  3. P.-H. Hsieh, C.-H. Shih, Y.-H. Chang, M. S. Lee, H.-N. Shih, and W.-E. Yang, “Two-stage revision hip arthroplasty for infection: comparison between the interim use of antibiotic-loaded cement beads and a spacer prosthesis,” Journal of Bone and Joint Surgery: American Volume, vol. 86, no. 9, pp. 1989–1997, 2004. View at Google Scholar · View at Scopus
  4. S. Kurtz, K. Ong, E. Lau, F. Mowat, and M. Halpern, “Projections of primary and revision hip and knee arthroplasty in the United States from 2005 to 2030,” The Journal of Bone and Joint Surgery Series A, vol. 89, no. 4, pp. 780–785, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. A. F. Engelsman, I. C. Saldarriaga-Fernandez, M. R. Nejadnik et al., “The risk of biomaterial-associated infection after revision surgery due to an experimental primary implant infection,” Biofouling, vol. 26, no. 7, pp. 761–767, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. B. Cui, P. M. Smooker, D. A. Rouch, A. J. Daley, and M. A. Deighton, “Differences between two clinical Staphylococcus capitis subspecies as revealed by biofilm, antibiotic resistance, and pulsed-field gel electrophoresis profiling,” Journal of Clinical Microbiology, vol. 51, no. 1, pp. 9–14, 2013. View at Publisher · View at Google Scholar · View at Scopus
  7. M. Otto, “Staphylococcal biofilms,” Current Topics in Microbiology and Immunology, vol. 322, pp. 207–228, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. C. R. Arciola, D. Campoccia, P. Speziale, L. Montanaro, and J. W. Costerton, “Biofilm formation in Staphylococcus implant infections. A review of molecular mechanisms and implications for biofilm-resistant materials,” Biomaterials, vol. 33, no. 26, pp. 5967–5982, 2012. View at Publisher · View at Google Scholar · View at Scopus
  9. W. Zimmerli, F. A. Waldvogel, P. Vaudaux, and U. E. Nydegger, “Pathogenesis of foreign body infection: description and characteristics of an animal model,” The Journal of Infectious Diseases, vol. 146, no. 4, pp. 487–497, 1982. View at Publisher · View at Google Scholar · View at Scopus
  10. N. Høiby, T. Bjarnsholt, M. Givskov, S. Molin, and O. Ciofu, “Antibiotic resistance of bacterial biofilms,” International Journal of Antimicrobial Agents, vol. 35, no. 4, pp. 322–332, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. W. Zimmerli and P. E. Ochsner, “Management of infection associated with prosthetic joints,” Infection, vol. 31, no. 2, pp. 99–108, 2003. View at Publisher · View at Google Scholar · View at Scopus
  12. D. Campoccia, L. Montanaro, and C. R. Arciola, “A review of the biomaterials technologies for infection-resistant surfaces,” Biomaterials, vol. 34, no. 34, pp. 8533–8554, 2013. View at Publisher · View at Google Scholar · View at Scopus
  13. S. Nag and R. Banerjee, “Fundamentals of medical implant materials,” in ASM Handbook, Volume 23: Materials for Medical Devices, pp. 6–17, ASM International, 2012. View at Google Scholar
  14. R. M. Donlan and J. W. Costerton, “Biofilms: Survival mechanisms of clinically relevant microorganisms,” Clinical Microbiology Reviews, vol. 15, no. 2, pp. 167–193, 2002. View at Publisher · View at Google Scholar · View at Scopus
  15. B. Mueller, T. Toeppel, M. Gebauer, and R. Neugebauer, “Innovative features in implants through Beam Melting—a new approach for additive manufacturing of endoprostheses,” in Innovative Developments in Virtual and Physical Prototyping, P. J. Bártolo, A. C. S. DeLemos, A. P. O. Tojeira et al., Eds., pp. 519–523, Taylor & Francis, London, UK, 2011. View at Google Scholar
  16. Y. Fu and W. J. Kao, “Drug release kinetics and transport mechanisms of non-degradable and degradable polymeric delivery systems,” Expert Opinion on Drug Delivery, vol. 7, no. 4, pp. 429–444, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. J. Crank, The Mathematics of Diffusion, Clarendon Press, Oxford, UK, 2nd edition, 1975.
  18. M. Grassi and G. Grassi, “Mathematical modelling and controlled drug delivery: matrix systems,” Current Drug Delivery, vol. 2, no. 1, pp. 97–116, 2005. View at Publisher · View at Google Scholar · View at Scopus
  19. R. W. Korsmeyer, R. Gurny, E. Doelker, P. Buri, and N. A. Peppas, “Mechanisms of solute release from porous hydrophilic polymers,” International Journal of Pharmaceutics, vol. 15, no. 1, pp. 25–35, 1983. View at Publisher · View at Google Scholar · View at Scopus
  20. P. Costa and J. M. Sousa Lobo, “Modeling and comparison of dissolution profiles,” European Journal of Pharmaceutical Sciences, vol. 13, no. 2, pp. 123–133, 2001. View at Publisher · View at Google Scholar · View at Scopus
  21. G. Jeon, S. Y. Yang, and J. K. Kim, “Functional nanoporous membranes for drug delivery,” Journal of Materials Chemistry, vol. 22, no. 30, pp. 14814–14834, 2012. View at Publisher · View at Google Scholar · View at Scopus
  22. British Pharmacopoeia, “Vancomycin intravenous infusion,” in British Pharmacopoeia, vol. 3, TSO, Norwich, UK, 2012. View at Google Scholar
  23. P. Unwin, 2014, http://presentation.willit3dprint.com/presentations/Paul%20Unwin%20-%20The%20use%20of%20Additive%20Manufacturing%20for%20the%20fabrication%20of%20specialised%20orthopaedic%20implants.pdf.
  24. L. Nickels, “World's first patient-specific jaw implant,” Metal Powder Report, vol. 67, no. 2, pp. 12–14, 2012. View at Publisher · View at Google Scholar · View at Scopus
  25. A. B. Arcam, “Additive Manufacturing with Electron Beam Melting (EBM),” 2014, http://www.rm-platform.com/index.php/downloads2/viewcategory/8-presentations.
  26. FDA, Exactech Novation InteGrip Acetabular Augments Special 510(k)-510(k) Summary of Safety and Effectiveness, USA Food and Drug Administration, 2014, http://www.accessdata.fda.gov/cdrh_docs/pdf11/K113609.pdf.
  27. P. Ohldin, “Series production of CE-certified orthopedic implants with integrated porous structures for improved bone ingrowth,” in Proceedings of the 21st International DAAAM Symposium, Vienna, Austria, October 2010.
  28. S. Y. Yang, J.-A. Yang, E.-S. Kim et al., “Single-file diffusion of protein drugs through cylindrical nanochannels,” ACS Nano, vol. 4, no. 7, pp. 3817–3822, 2010. View at Publisher · View at Google Scholar · View at Scopus
  29. K. A. Poelstra, N. A. Barekzi, A. M. Rediske, A. G. Felts, J. B. Slunt, and D. W. Grainger, “Prophylactic treatment of gram-positive and gram-negative abdominal implant infections using locally delivered polyclonal antibodies,” Journal of Biomedical Materials Research, vol. 60, no. 1, pp. 206–215, 2002. View at Publisher · View at Google Scholar · View at Scopus
  30. A. Scharfenberger, M. Clark, G. Lavoie, G. O'Connor, E. Massen, and L. A. Beaupre, “Treatment of an infected total hip replacement with the PROSTALAC system Part 1: infection resolution,” Canadian Journal of Surgery, vol. 50, no. 1, pp. 24–28, 2007. View at Google Scholar · View at Scopus