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BioMed Research International
Volume 2015, Article ID 857642, 7 pages
Clinical Study

Magnetic Resonance Comparison of Left-Right Heart Volumetric and Functional Parameters in Thalassemia Major and Thalassemia Intermedia Patients

1Department of Radiology, A.O.R.N. Cardarelli, Via Antonio Cardarelli 9, 80100 Naples, Italy
2Department of Diagnostic Imaging, Campus Bio-Medico University, Via Alvaro del Portillo 200, 00128 Rome, Italy
3Unit of Measurements and Biomedical Instrumentation, Campus Bio-Medico University, Via Alvaro del Portillo 200, 00128 Rome, Italy
4Department of Hematology, Sant’Eugenio Hospital, Piazzale dell’Umanesimo 10, 00143 Rome, Italy

Received 10 December 2014; Revised 4 March 2015; Accepted 6 March 2015

Academic Editor: Cristiana Corsi

Copyright © 2015 Carlo Liguori et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objectives. To evaluate a population of asymptomatic thalassemia major (TM) and thalassemia intermedia (TI) patients using cardiovascular magnetic resonance (CMR). We supposed that TI group could be differentiated from the TM group based on and that the TI group could demonstrate higher cardiac output. Methods. A retrospective analysis of 242 patients with TM and TI was performed (132 males, 110 females; mean age years; 186 TM, 56 TI). Iron load was assessed by measurements; volumetric functions were analyzed using steady-state-free precession sequences. Results. Significant difference in left-right heart performance was observed between TM with iron overload and TI patients and between TM with iron overload and TM without iron overload (); no significant differences were observed between TM without iron overload and TI patients. A significant correlation was observed between and ejection fraction of right ventricle- (RV-) ejection fraction of left ventricle (LV); an inverse correlation was present among values and end-diastolic volume of LV, end-systolic volume of LV, stroke volume of LV, end-diastolic volume of RV, end-systolic volume of RV, and stroke volume of RV. Conclusions. CMR is a leading approach for cardiac risk evaluation of TM and TI patients.