Ghrelin Improves Functional Survival of Engrafted Adipose-Derived Mesenchymal Stem Cells in Ischemic Heart through PI3K/Akt Signaling Pathway

Figure 4

Significant reduction of fibrosis and cardiomyocytes apoptosis after ADMSCs implantation. (a) Representative images of Masson’s trichrome staining of each group 4 weeks after MI; (b) quantitative analysis of Masson’s trichrome staining; (c) representative images of myocardial sections TUNEL (green, TUNEL; blue, DAPI; scale bar, 100 μm); (d) quantification of apoptotic cells; (e) analysis of caspase-3 activity. versus MI group, versus MI group, and versus ADMSC group.

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