Hypoglycaemia, Abnormal Lipids, and Cardiovascular Disease among Chinese with Type 2 Diabetes

Table 4

Sensitivity analysis of odds ratio of hypoglycaemia and lipid profiles for cardiovascular disease after exclusion of 408 patients who used lipid lowering drugs.

	OR (95% CI)	value
Hypoglycaemia for CVD
Model one		<0.0001
Nonhyperglycemia	Reference
Mild hyperglycemia	2.86 (2.04–4.02)
Severe hyperglycemia	7.72 (4.73–12.60)
Model two		<0.0001
Nonhyperglycemia	Reference
Mild hyperglycemia	2.95 (2.02–4.29)
Severe hyperglycemia	6.75 (3.79–12.04)
Model three		<0.0001
Nonhyperglycemia	Reference
Mild hyperglycemia	2.95 (2.02–4.29)
Severe hyperglycemia	6.75 (3.79–12.04)
Lipid profile for CVD
Model four
LDL cholesterol, mmol/L	1.06 (0.94–1.20)	0.3604
HDL cholesterol, mmol/L	0.79 (0.70–0.89)	<0.0001
Triglyceride, mmol/L	1.09 (1.02–1.16)	0.0165
Model five
LDL cholesterol, mmol/L	0.93 (0.80–1.09)	0.3755
HDL cholesterol, mmol/L	0.91 (0.82–1.03)	0.1201
Triglyceride, mmol/L	1.07 (0.99–1.16)	0.0739
Model six
LDL cholesterol, mmol/L	0.91 (0.77–1.07)	0.2469
HDL cholesterol, mmol/L	0.88 (0.77–1.00)	0.0580
Triglyceride, mmol/L	1.08 (1.00–1.17)	0.0593

Model one: not adjusted for other variables.
Model two: adjusted for age, sex, BMI, systolic blood pressure and log-transformed urinary albumin to creatinine ratio, and drug use (statins, other lipid lowering drugs, renin-angiotensin system inhibitors, oral antidiabetes drugs [OADs] only, glucagon-like peptide-1 based treatment, basal insulin based treatment, and premixed insulin based treatment).
Model three: further adjusted for LDL-C, HDL-C, and triglyceride.
Model four: not adjusted for other variables.
Model five: adjusted for age, sex, BMI, systolic blood pressure, LDL-C, HDL-C, triglyceride and log-transformed urinary albumin to creatinine ratio, and drug use (statins, other lipid lowering drugs, renin-angiotensin system inhibitors, oral antidiabetes drugs [OADs] only, glucagon-like peptide-1 based treatment, basal insulin based treatment, and premixed insulin based treatment).
Model six: adjusted for the variables listed in model five and hypoglycaemia.