Tanshinone IIA Attenuates Renal Fibrosis after Acute Kidney Injury in a Mouse Model through Inhibition of Fibrocytes Recruitment

Figure 3

Tanshinone IIA inhibits fibronectin expression in the kidney 28 days after folic acid injury. (a) Representative images of fibronectin expression at day 28 stained by immunofluorescence (original magnification ×100). (b) Semiquantification of kidney fibronectin deposition from (a). (c) Representative immunoblots and semiquantification (d) of fibronectin in kidney cortical tissue lysates at day 28. Data are expressed as the mean ± SEM (). ^★ versus group TS; ^★★ versus group FA. Notes: Ctrl: mice treated with vehicle alone; TS: mice treated with Tanshinone IIA alone; FA: folic acid-treated mice followed by vehicle treatment; FA + TS: folic acid-treated mice subjected to Tanshinone IIA injection for 3 consecutive days.

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