Tanshinone IIA Attenuates Renal Fibrosis after Acute Kidney Injury in a Mouse Model through Inhibition of Fibrocytes Recruitment

Figure 4

Tanshinone IIA inhibits recruitment of fibrocytes into the folic acid-injured kidney. (a) Representative images of fibrocytes in the kidney (yellow arrows), determined by dual staining of CD45 (green color) and collagen I (red color) in the kidney. (b) Quantification of fibrocytes in kidney sections evaluated in five random fields per section and five sections per kidney. Data are expressed as the mean ± SEM (). ^★ versus group TS; ^★★ versus group FA. Notes: Ctrl: mice treated with vehicle alone; TS: mice treated with Tanshinone IIA alone; FA: folic acid-treated mice followed by vehicle treatment; FA + TS: folic acid-treated mice subjected to Tanshinone IIA injection for 3 consecutive days.

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