Tanshinone IIA Attenuates Renal Fibrosis after Acute Kidney Injury in a Mouse Model through Inhibition of Fibrocytes Recruitment

Figure 5

Tanshinone IIA inhibits TGF-β1 expression in folic acid-injured kidney at day 3. (a) Representative images and semiquantification (b) of TGF-β1 (original magnification ×400) stained by immunohistochemistry in the kidney sections at day 3. (c) Representative immunoblot and quantification (d) of TGF-β1 in kidney cortical tissue lysates at day 3. Data are expressed as the mean ± SEM (). ^★ versus group TS; ^★★ versus group FA. Notes: transforming growth factor-beta 1 (TGF-β1); Ctrl: mice treated with vehicle alone; TS: mice treated with Tanshinone IIA alone; FA: folic acid-treated mice followed by vehicle treatment; FA + TS: folic acid-treated mice subjected to Tanshinone IIA injection for 3 consecutive days.

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