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BioMed Research International
Volume 2015, Article ID 867140, 10 pages
http://dx.doi.org/10.1155/2015/867140
Research Article

Tanshinone IIA Attenuates Renal Fibrosis after Acute Kidney Injury in a Mouse Model through Inhibition of Fibrocytes Recruitment

1Department of Nephrology, Affiliated Nanjing Drum Tower Hospital, Medical School of Nanjing University, Nanjing 21008, China
2Department of Medicine, Rhode Island Hospital, Brown University School of Medicine, Providence, RI 02903, USA
3Department of Cardiology, Affiliated Nanjing Drum Tower Hospital, Medical School of Nanjing University, Nanjing 21008, China

Received 9 October 2015; Accepted 1 December 2015

Academic Editor: Jeremiah R. Brown

Copyright © 2015 Chunming Jiang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Flow cytometric analysis on circulating fibrocytes showed that the number of fibrocytes was significantly increased 3 days after folic acid injection. Tanshinone IIA administration drastically inhibited this effect of folic acid. Our data suggests that Tanshinone IIA may reduce the number of fibrocytes in the folic acid injured kidney by decreasing the amount of circulating fibrocytes.

  1. Supplementary Material