Activity of BKM120 and BEZ235 against Lymphoma Cells

Figure 5

HUT78 cells were treated for 24 hours with increasing concentrations of BKM120 and BEZ235 as well as with the microtubule destabilizer nocodazole (1 μM) and the microtubule stabilizer paclitaxel (100 nM). Representative data from analyses of cell cycle arrest in G2 (a), tubulin polymerization (b), and cell viability (c) after BKM120 treatment. Representative data from analyses of cell cycle arrest in G2 (d), tubulin polymerization (e), and cell viability (f) after BEZ235 treatment. Data are expressed as mean ± SD and were obtained from three independent experiments performed in triplicate (Nocod = nocodazole; Paclitax = paclitaxel) compared with control.

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