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BioMed Research International
Volume 2015, Article ID 870987, 8 pages
Research Article

Strategy for the Management of Macular Edema in Retinal Vein Occlusion: The European VitreoRetinal Society Macular Edema Study

1Yale Eye Center, 40 Temple Street No. 3d, New Haven, CT 06510, USA
2Eyecare Medical Group, 53 Sewall Street, Portland, ME 04102, USA
3Augenklinik Universitätsallee Bremen GmbH, Parkallee 301/Universitätsallee, 28213 Bremen, Germany
4Cairo University, Cairo University Road, Oula, Giza, Egypt
5European VitreoRetinal Society, 8 rue Camille Flammarion, 44000 Nantes, France

Received 17 April 2014; Revised 28 June 2014; Accepted 30 June 2014

Academic Editor: Jerzy Nawrocki

Copyright © 2015 Ron A. Adelman et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. To compare the efficacy of different therapies in the treatment of macular edema associated with retinal vein occlusion (RVO). Design. This is a nonrandomized, multicenter collaborative study. Participants. 86 retina specialists from 29 countries provided clinical information, including choice of treatment and outcome, on 2,603 patients with macular edema including 738 cases of RVO. Methods. Reported data included the type and number of treatments performed, visual acuities, and other clinical and diagnostic findings. Main Outcome Measures. The mean increase in visual acuity and mean number of treatments performed. Results. 358 cases of central retinal vein occlusion (CRVO) and 380 cases of branch retinal vein occlusion (BRVO) were included in this investigation. Taking all RVO cases together, pars plana vitrectomy with internal limiting membrane (ILM) peeling alone resulted in an improvement in vision greater than other therapies. Those treated with intravitreal antivascular endothelial growth factor (anti-VEGF) injection alone showed the second greatest improvement in vision. Dexamethasone intravitreal implant alone and intravitreal triamcinolone alone both resulted in modest visual gains. Conclusions. In the treatment of macular edema in RVO, vitrectomy with ILM peeling may achieve visual improvement and may be a good option for certain cases. Anti-VEGF injection is the most effective of the nonsurgical treatments.