Research Article
Cost-Effectiveness of Anticoagulation in Patients with Nonvalvular Atrial Fibrillation with Edoxaban Compared to Warfarin in Germany
Table 3
Base-case values and ranges for costs used in sensitivity analyses for NOACs.
| | Variable | Edoxaban 30 mg | Edoxaban 60 mg | Ref | Dabigatran
110 mg bid | Dabigatran
bid 150 mg | Ref
[5] | Rivaroxaban | Ref
[5] | Apixaban | Ref
[5] |
| | Costs | | | | | | | | | | | | Daily cost of medicine (euro) | | | | | | | | | | | | NOAC | 3.37 (0.00–5.00) | 3.37 (0.00–5.00) | Ass | 3.38 (0.00–5.00) | 3.38 (0.00–5.00) | [26] | 3.20 (0.00–5.00) | [26] | 3.54 (0.00–5.00) | [26] | | Warfarin | 0.20 (0.00–1.00) | 0.20 (0.00–1.00) | [26] | 0.20 (0.00–1.00) | 0.20 (0.00–1.00) | [26] | 0.20 (0.00–1.00) | [26] | 0.20 (0.00–1.00) | [26] | | Costs per INR determination | 0.64 (0.46–0.79) | 0.64 (0.46–0.79) | Ass | 0.64 (0.46–0.79) | 0.64 (0.46–0.79) | Ass | 0.64 (0.46–0.79) | Ass | 0.64 (0.46–0.79) | Ass | One-time costs of neurologic event
(stroke or intracranial hemorrhage) (euro) | | | | | | | | | | | | Serious | 7 000 (901–46 558) | 7 000 (901–46 558) | [14] | 7 000 (901–46 558) | 7 000 (901–46 558) | [14] | 7 000 (901–46 558) | [14] | 7 000 (901–46 558) | [14] | | Moderate | 4 233 (901–46 558) | 4 233 (901–46 558) | [14] | 4 233 (901–46 558) | 4 233 (901–46 558) | [14] | 4 233 (901–46 558) | [14] | 4 233 (901–46 558) | [14] | | Mild | 3 942 (2 014–4 233) | 3 942 (2 014–4 233) | [14] | 3 942 (2 014–4 233) | 3 942 (2 014–4 233) | [14] | 3 942 (2 014–4 233) | [14] | 3 942 (2 014–4 233) | [14] | One-time costs for myocardial infarction
(euro) | 10 000 (2 743–48 023) | 10 000 (2 743–48 023) | [14] | 10 000 (2 743–48 023) | 10 000 (2 743–48 023) | [14] | 10 000 (2 743–48 023) | [14] | 10 000 (2 743–48 023) | [14] | | One-time costs for hemorrhage (euro) | | | | | | | | | | | | Major hemorrhage | 2 500 (891–5 415) | 2 500 (891–5 415) | [23] | 2 500 (891–5 415) | 2 500 (891–5 415) | [23] | 2 500 (891–5 415) | [23] | 2 500 (891–5 415) | [23] | | Minor hemorrhage | 50 (0.00–100) | 50 (0.00–100) | Ass | 50 (0.00–100) | 50 (0.00–100) | Ass | 50 (0.00–100) | Ass | 50 (0.00–100) | Ass | | Rehabilitation costs (euro) | | | | | | | | | | | | Annual ambulant rehabilitation costs | 2 300 (1 800–2 800) | 2 300 (1 800–2 800) | [43] | 2 300 (1 800–2 800) | 2 300 (1 800–2 800) | [43] | 2 300 (1 800–2 800) | [43] | 2 300 (1 800–2 800) | [43] | | Inpatient rehabilitation costs per patient | 8 000 (2 000–14 000) | 8 000 (2 000–14 000) | [43] | 8 000 (2 000–14 000) | 8 000 (2 000–14 000) | [43] | 8 000 (2 000–14 000) | [43] | 8 000 (2 000–14 000) | [43] | | Annual costs for further medical treatment | 2 900 (2 300–4 000) | 2 900 (2 300–4 000) | [43] | 2 900 (2 300–4 000) | 2 900 (2 300–4 000) | [43] | 2 900 (2 300–4 000) | [43] | 2 900 (2 300–4 000) | [43] | | Costs in case of death (euro) | 2 500 | 2 500 | [14] | 2 500 | 2 500 | [14] | 2 500 | [14] | 2 500 | [14] | | Discounting (%) | 5 (0–10) | 5 (0–10) | [9, 10, 24] | 5 (0–10) | 5 (0–10) | [9, 10, 24] | 5 (0–10) | [9, 10, 24] | 5 (0–10) | [9, 10, 24] |
|
|
Ref = reference; Ass = assumption.
|
