New Derivatives of Pyridoxine Exhibit High Antibacterial Activity against Biofilm-Embedded Staphylococcus Cells

Table 1

Minimum inhibitory concentrations (MICs, μg/mL) and minimum bactericidal concentrations (MBCs, μg/mL of compounds against S. aureus and S. epidermidis in Mueller-Hinton (Basal medium) broth).

Compound	Staphylococcus aureus		Staphylococcus epidermidis		CC50 for HEK-293 cells, μg/mL [9–11]
	MIC	MBC	MIC	MBC
Miramistin	1 (2)	8 (8)	1 (2)	4 (4)	1.5
Ciprofloxacin hydrochloride	0.5 (2)	8 (8)	1 (2)	4 (4)	ND
Vancomycin	4 (4)	ND	4 (4)	ND	ND
1	2 (4)	8 (8)	2 (4)	8 (8)	1.3
2	2 (4)	16 (16)	2 (4)	16 (16)	5.4
3	2 (4)	8 (8)	2 (4)	8 (8)	1.4
4	2 (2)	16 (32)	2 (2)	16 (16)	72
5	2 (4)	32 (32)	2 (2)	32 (32)	200
6	1 (1)	16 (16)	1 (1)	16 (16)	3

Not determined.