PPARα Agonist WY-14643 Induces SIRT1 Activity in Rat Fatty Liver Ischemia-Reperfusion Injury

Figure 4

Implication of WY-14643 administration in ERS parameters in steatotic livers subjected to ischemia-reperfusion. Western blot and densitometric analysis of (a) IRE1α, (b) p-eIf2, (c) caspase 12, and (d) CHOP. Sham: anesthesia and laparotomy, IR: 60 min partial ischemia and 24 h of reperfusion, and WY-14643 + IR: iv administration of WY-14643 (10 mg/kg) 1 hour before IR. versus Sham; versus IR.

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