Calreticulin Binds to Fas Ligand and Inhibits Neuronal Cell Apoptosis Induced by Ischemia-Reperfusion Injury

Figure 2

CRT binds to FasL on the surface of neurons after ischemia. (a) Immunofluorescent staining of the cortexes of sham and MCAO mice. (b) Confocal microscopy images of immunostained normal SH-SY5Y cells and OGD-exposed SH-SY5Y cells at 3 h after reperfusion. (c1, 2) Co-IP of CRT and FasL in the cortexes of sham and MCAO mice. (d1, 2) Co-IP of Fas and FasL in normal SH-SY5Y cells and OGD-exposed SH-SY5Y cells cultured with or without 40 ng/mL CRT. , versus control, and ^### versus OGD group. repeats.