Icariin Intervenes in Cardiac Inflammaging through Upregulation of SIRT6 Enzyme Activity and Inhibition of the NF-Kappa B Pathway

Figure 1

The effect of varying concentrations of ICA on the activation of SIRT6 enzyme activity. Concentrations of ICA were in  mol/L, where = 4, 6, 8, 10, 12, 14, 16. The SIRT6 direct fluorescent screening assay was carried out as described in Section 2.6. ICA shows a low % activation effect on the enzymatic activity of SIRT6 in high concentrations of ICA (10⁻⁴ mol/L). With decreasing concentrations of ICA, the percent activation effect on SIRT6 enzyme activity increases and peaks at an ICA concentration of 10⁻⁸ mol/L.