The Effect of Bicarbonate Administration via Continuous Venovenous Hemofiltration on Acid-Base Parameters in Ventilated Patients
Table 2
Baseline patient characteristics by partial arterial pressure of carbon dioxide at time of continuous venovenous hemofiltration initiationa.
Patients
CO2 ≤ 40 mmHg
CO2 > 40 mmHg
()b
()
()
Age
57.5 ± 15.4
61.8 ± 17.3
55.2 ± 13.0
Male
13 (68.4)
6 (66.7)
7 (77.8)
ICU type
Medical
7 (36.8)
3 (33.3)
3 (33.3)
Surgicalc
7 (36.8)
4 (44.5)
3 (33.3)
Cardiac
5 (26.2)
2 (22.2)
3 (33.3)
ICU admission diagnosis
Sepsis
5 (26.3)
2 (22.2)
2 (22.2)
Heart failure/cardiogenic shock
6 (31.6)
1 (11.1)
5 (55.6)
Respiratory failure/pneumonia
7 (36.8)
5 (55.6)
2 (22.2)
Other causesd
1 (5.3)
1 (11.1)
0
Preexisting comorbid condition
Hypertension
10 (52.6)
5 (55.6)
5 (55.6)
Coronary artery disease
5 (26.3)
1 (11.1)
4 (44.4)
Chronic kidney diseasee
7 (36.8)
2 (22.2)
5 (55.6)
Diabetes mellitus
10 (52.6)
2 (22.2)
7 (77.8)
Liver disease
1 (5.3)
0
0
COPD
6 (31.5)
3 (33.3)
2 (22.2)
Cancer
7 (36.8)
3 (33.3)
4 (44.4)
Systolic blood pressure (mmHg)
95.6 ± 16.2
100.8 ± 14.4
89.3 ± 17.3
Vasopressor dependency
14 (73.7)
6 (66.7)
8 (88.9)
Urine output (mL)f
14.6 (17.1)
12.6 ± 17.4
17.2 ± 18.4
SOFA scoreg
13.4 ± 3.5
12.8 ± 4.1
14.0 ± 2.7
pHg
7.32 ± 0.12
7.40 ± 0.06
7.24 ± 0.12
Creatinine (mg/dL)
3.9 ± 1.2
3.8 ± 1.0
3.8 ± 1.3
Blood urea nitrogen (mg/dL)
68.4 ± 35.8
57.2 ± 29.4
72.1 ± 36.3
Potassium (mmol/L)
4.9 ± 1.0
4.5 ± 1.2
5.2 ± 0.8
Lactate (mmol/L)h
4.1 ± 4.9
4.7 ± 5.6
3.4 ± 4.2
White blood cell count (K/L)
15.7 ± 6.6
15.6 ± 5.5
17.1 ± 7.1
Platelets (K/L)
135 ± 111
120 ± 90
163 ± 130
Mortality within 7 days of CVVH initiation
2 (10.5)
0
2 (22.2)
Values presented as mean ± standard deviation or (%).
b1 of 19 patients did not have a starting arterial blood gas.
cIncluding surgical, cardiothoracic, and cardiac surgery ICUs.
dRetroperitoneal bleed.
eIncluding 1 end stage renal disease patient on dialysis.
fUrine output in 1-hour period prior to starting CVVH. . for all patients, for CO2 ≤ 40 mmHg, and for CO2 > 40 mmHg. ICU: intensive care unit; CVVH: continuous venovenous hemofiltration; COPD: chronic obstructive pulmonary disease, K: 1000, and CO2: partial arterial pressure of carbon dioxide.
