Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2015, Article ID 906039, 6 pages
http://dx.doi.org/10.1155/2015/906039
Research Article

The Differential Effects of a Selective Kappa-Opioid Receptor Agonist, U50488, in Guinea Pig Heart Tissues

1School of Medicine, Fu Jen Catholic University, No. 510 Zhongzheng Road, Xinzhuang District, New Taipei City 24205, Taiwan
2Big Data Research Centre, Fu Jen Catholic University, New Taipei City, Taiwan
3Department of Chemistry, Fu Jen Catholic University, New Taipei City, Taiwan
4Department of Cardiology, Tainan Municipal Hospital, No. 670 Chongde Road, East District, Tainan 70173, Taiwan
5Department of Pharmacology, College of Medicine, National Taiwan University, No. 1 Jen-Ai Road, Section 1, Zhongzheng District, Taipei 10051, Taiwan

Received 11 July 2014; Revised 2 November 2014; Accepted 4 November 2014

Academic Editor: Adair Santos

Copyright © 2015 Chi-Feng Hung et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. P. Sobanski, M. Krajnik, M. Shaqura, E. Bloch-Boguslawska, M. Schäfer, and S. A. Mousa, “The presence of mu-, delta-, and kappa-opioid receptors in human heart tissue,” Heart and Vessels, vol. 29, no. 6, pp. 855–863, 2014. View at Publisher · View at Google Scholar · View at Scopus
  2. K. Tanaka, J. R. Kersten, and M. L. Riess, “Opioid-induced cardioprotection,” Current Pharmaceutical Design, vol. 20, no. 36, pp. 5696–5705, 2014. View at Google Scholar
  3. M. M. Theisen, S. Schlottmann, C. August et al., “Detection and distribution of opioid peptide receptors in porcine myocardial tissue,” Pharmacological Research, vol. 84, pp. 45–49, 2014. View at Publisher · View at Google Scholar · View at Scopus
  4. T. V. Lasukova, L. N. Maslov, S. W. Nizkodubova, A. S. Gorbunov, and S. Y. Zibulnikov, “Role of intracellular calcium and cyclic nucleotides in realization of cardioprotective effects of δ1- and κ1-Opioid receptor agonists,” Bulletin of Experimental Biology and Medicine, vol. 148, no. 6, pp. 877–880, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. L.-W. Fu and J. C. Longhurst, “Functional role of peripheral opioid receptors in the regulation of cardiac spinal afferent nerve activity during myocardial ischemia,” American Journal of Physiology: Heart and Circulatory Physiology, vol. 305, no. 1, pp. H76–H85, 2013. View at Publisher · View at Google Scholar · View at Scopus
  6. C.-F. Hung, W.-L. Chang, H.-C. Liang, and M.-J. Su, “Identification of opioid receptors in the sympathetic and parasympathetic nerves of guinea-pig atria,” Fundamental & Clinical Pharmacology, vol. 14, no. 4, pp. 387–394, 2000. View at Publisher · View at Google Scholar · View at Scopus
  7. C. Bolte, G. Newman, and J. E. J. Schultz, “Kappa and delta opioid receptor signaling is augmented in the failing heart,” Journal of Molecular and Cellular Cardiology, vol. 47, no. 4, pp. 493–503, 2009. View at Publisher · View at Google Scholar · View at Scopus
  8. T. V. Lasukova, L. N. Maslov, A. A. Platonov, N. V. Guzarova, and I. B. Lishmanov, “Role of kappa1 opioid receptors and cAMP in regulation of cardiac tolerance to ischemia and reperfusion,” Izvestiia Akademii Nauk, no. 5, pp. 580–588, 2008. View at Google Scholar · View at Scopus
  9. Q.-Y. Zhang, W. Wang, Q.-X. Shi et al., “Antiarrhythmic effect mediated by κ-opioid receptor is associated with Cx43 stabilization,” Critical Care Medicine, vol. 38, no. 12, pp. 2365–2376, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. L. O. Karlsson, N. Bergh, L. Li et al., “Dose-dependent cardioprotection of enkephalin analogue Eribis peptide 94 and cardiac expression of opioid receptors in a porcine model of ischaemia and reperfusion,” European Journal of Pharmacology, vol. 674, no. 2-3, pp. 378–383, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. A. Y. Lishmanov, L. N. Maslov, T. V. Lasukova, D. Crawford, and T. M. Wong, “Activation of k1-opioid receptor as a method for prevention of ischemic and reperfusion arrhythmias: role of protein kinase C and KATP channels,” Bulletin of Experimental Biology and Medicine, vol. 143, no. 2, pp. 187–190, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. L. Cheng, S. Ma, L.-X. Wei et al., “Cardioprotective and antiarrhythmic effect of U50,488H in ischemia/reperfusion rat heart,” Heart and Vessels, vol. 22, no. 5, pp. 335–344, 2007. View at Publisher · View at Google Scholar · View at Scopus
  13. J.-Z. Sheng and T.-M. Wong, “Chronic U50,488H abolishes inositol 1,4,5-trisphosphate and intracellular Ca2+ elevations evoked by κ-opioid receptor in rat myocytes,” European Journal of Pharmacology, vol. 307, no. 3, pp. 323–329, 1996. View at Publisher · View at Google Scholar · View at Scopus
  14. C.-M. Cao, Q. Xia, Y.-Y. Chen, X. Zhang, and Y.-L. Shen, “Opioid receptor-mediated effects of interleukin-2 on the [Ca2+]i transient and contraction in isolated ventricular myocytes of the rat,” Pflugers Archiv European Journal of Physiology, vol. 443, no. 4, pp. 635–642, 2002. View at Publisher · View at Google Scholar · View at Scopus
  15. T. Kanemasa, K. Asakura, and M. Ninomiya, “κ-Opioid agonist U50488 inhibits P-type Ca2+ channels by two mechanisms,” Brain Research, vol. 702, no. 1-2, pp. 207–212, 1995. View at Publisher · View at Google Scholar · View at Scopus
  16. B. Hassan and V. Ruiz-Velasco, “The κ-opioid receptor agonist U-50488 blocks Ca2+ channels in a voltage- and G protein-independent manner in sensory neurons,” Regional Anesthesia & Pain Medicine, vol. 38, no. 1, pp. 21–27, 2013. View at Publisher · View at Google Scholar · View at Scopus
  17. D. Chao and Y. Xia, “Ionic storm in hypoxic/ischemic stress: can opioid receptors subside it?” Progress in Neurobiology, vol. 90, no. 4, pp. 439–470, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. M. Chen, J.-J. Zhou, K. W.-L. Kam et al., “Roles of KATP channels in delayed cardioprotection and intracellular Ca2+ in the rat heart as revealed by kappa-opioid receptor stimulation with U50488H,” British Journal of Pharmacology, vol. 140, no. 4, pp. 750–758, 2003. View at Publisher · View at Google Scholar
  19. W. A. Macdonald, O. B. Nielsen, and T. Clausen, “Effects of calcitonin gene-related peptide on rat soleus muscle excitability: mechanisms and physiological significance,” American Journal of Physiology: Regulatory Integrative and Comparative Physiology, vol. 295, no. 4, pp. R1214–R1223, 2008. View at Publisher · View at Google Scholar · View at Scopus
  20. K. B. Olsen, T. H. Braunstein, C. M. Sørensen, L. N. Axelsen, N. H. Holstein-Rathlou, and M. S. Nielsen, “Angiotensin II does not acutely regulate conduction velocity in rat atrial tissue,” Scandinavian Journal of Clinical and Laboratory Investigation, vol. 71, no. 6, pp. 492–499, 2011. View at Publisher · View at Google Scholar
  21. A. Pousti, T. Deemyad, G. Malihi, and K. Brumand, “A preliminary study on the interaction of fluvoxamine and adenosine receptor on isolated guinea-pig atria,” International Journal of Neuroscience, vol. 116, no. 12, pp. 1491–1499, 2006. View at Publisher · View at Google Scholar · View at Scopus
  22. F. Speroni, A. Rebolledo, S. Salemme, M. C. Añón, F. Tanzi, and V. Milesi, “Genistein inhibits contractile force, intracellular Ca2+ increase and Ca2+ oscillations induced by serotonin in rat aortic smooth muscle,” Journal of Physiology and Biochemistry, vol. 63, no. 2, pp. 143–152, 2007. View at Publisher · View at Google Scholar · View at Scopus
  23. A. Kovács, L. G. Hársing Jr., and G. Szénási, “Vasoconstrictor 5-HT receptors in the smooth muscle of the rat middle cerebral artery,” European Journal of Pharmacology, vol. 689, no. 1–3, pp. 160–164, 2012. View at Publisher · View at Google Scholar · View at Scopus
  24. J. Utz, R. Eckert, and W. Trautwein, “Inhibition of L-type calcium currents in guinea pig ventricular myocytes by the κ-opioid agonist U50488h does not involve binding to opiate receptors,” Journal of Pharmacology and Experimental Therapeutics, vol. 274, no. 2, pp. 627–633, 1995. View at Google Scholar · View at Scopus
  25. T. R. L. Romero, L. S. Guzzo, and I. D. G. Duarte, “Mu, Delta, and Kappa opioid receptor agonists induce peripheral antinociception by activation of endogenous noradrenergic system,” Journal of Neuroscience Research, vol. 90, no. 8, pp. 1654–1661, 2012. View at Publisher · View at Google Scholar · View at Scopus
  26. F. Niroomand, R. A. Mura, L. Piacentini, and W. Kübler, “Opioid receptor agonists activate pertussis toxin-sensitive G proteins and inhibit adenylyl cyclase in canine cardiac sarcolemma,” Naunyn-Schmiedeberg's Archives of Pharmacology, vol. 354, no. 5, pp. 643–649, 1996. View at Google Scholar · View at Scopus
  27. J. E. de Menezes-Filho, A. N. Santana Gondim, J. Santos Cruz et al., “Geraniol blocks calcium and potassium channels in the mammalian myocardium: useful effects to treat arrhythmias,” Basic & Clinical Pharmacology & Toxicology, 2014. View at Publisher · View at Google Scholar
  28. M. Zhao, J. Zhao, G. He, X. Sun, X. Huang, and L. Hao, “Effects of astragaloside IV on action potentials and ionic currents in guinea-pig ventricular myocytes,” Biological and Pharmaceutical Bulletin, vol. 36, no. 4, pp. 515–521, 2013. View at Publisher · View at Google Scholar · View at Scopus
  29. K. Ishihara, N. Sarai, K. Asakura, A. Noma, and S. Matsuoka, “Role of Mg2+ block of the inward rectifier K+ current in cardiac repolarization reserve: a quantitative simulation,” Journal of Molecular and Cellular Cardiology, vol. 47, no. 1, pp. 76–84, 2009. View at Publisher · View at Google Scholar · View at Scopus
  30. M. Yamada, K. Ohta, A. Niwa, N. Tsujino, T. Nakada, and M. Hirose, “Contribution of L-type Ca2+ channels to early afterdepolarizations induced by IKr and IKs channel suppression in guinea pig ventricular myocytes,” Journal of Membrane Biology, vol. 222, no. 3, pp. 151–166, 2008. View at Publisher · View at Google Scholar · View at Scopus
  31. Y.-H. Choi, D. B. Cowan, T. C. W. Wahlers, R. Hetzer, P. J. del Nido, and C. Stamm, “Calcium sensitisation impairs diastolic relaxation in post-ischaemic myocardium: implications for the use of Ca2+ sensitising inotropes after cardiac surgery,” European Journal of Cardio-Thoracic Surgery, vol. 37, no. 2, pp. 376–383, 2010. View at Publisher · View at Google Scholar · View at Scopus
  32. W. R. Ford, A. S. Clanachan, C. Robin Hiley, and B. I. Jugdutt, “Angiotensin II reduces infarct size and has no effect on post-ischaemic contractile dysfunction in isolated rat hearts,” British Journal of Pharmacology, vol. 134, no. 1, pp. 38–45, 2001. View at Publisher · View at Google Scholar · View at Scopus
  33. T. Bragadeesh, A. R. Jayaweera, M. Pascotto et al., “Post-ischaemic myocardial dysfunction (stunning) results from myofibrillar oedema,” Heart, vol. 94, no. 2, pp. 166–171, 2008. View at Publisher · View at Google Scholar · View at Scopus
  34. Y. Wu, J. Wan, W.-Z. Zhen et al., “The effect of butorphanol postconditioning on myocardial ischaemia reperfusion injury in rats,” Interactive Cardiovascular and Thoracic Surgery, vol. 18, no. 3, pp. 308–312, 2014. View at Publisher · View at Google Scholar · View at Scopus