Assessment of Functional Characteristics of Amnestic Mild Cognitive Impairment and Alzheimer’s Disease Using Various Methods of Resting-State FMRI Analysis
Table 3
Brain regions with significant differences in amplitude of low-frequency fluctuations (ALFF) index between healthy subjects and patients with aMCI or AD.
Brain regions
R/L
Coordinates (mm)
Peak values
Voxels
Healthy subjects versus aMCI versus AD
Superior temporal gyrus
R
48
4
2
24.71
20320
Medial frontal gyrus
L
0
54
8
21.73
1412
Cerebellum
L
−24
−76
−50
20.83
1019
Parahippocampal gyrus
R
14
−6
−16
19.93
586
Cerebellum
R
20
−86
−40
13.57
573
Parahippocampal gyrus
R
16
−36
0
19.95
491
Middle frontal gyrus
R
20
30
42
9.51
279
Parahippocampal gyrus
R
36
−40
−4
14.35
270
Insula
R
24
28
10
17.84
258
Superior frontal gyrus
L
−18
34
44
9.96
230
Caudate
R
10
12
10
24.43
184
Superior frontal gyrus
L
−50
16
−32
12.75
166
Middle frontal gyrus
L
−24
−4
48
10.47
154
Threshold: corrected < 0.05 (uncorrected individual voxel height threshold of < 0.01, > 4.776 with a minimum cluster size of 864 mm3).
