Assessment of Functional Characteristics of Amnestic Mild Cognitive Impairment and Alzheimer’s Disease Using Various Methods of Resting-State FMRI Analysis

Table 7

Results of post hoc two-sample -tests between each pair of the healthy subjects and patients with AD and aMCI groups in ALFF approach.

Brain regions	R/L	Coordinates; (mm)			Peak; value	Voxels
		Healthy subject versus aMCI
Inferior parietal lobule	R	56	−46	24	3.87	729
Supramarginal gyrus	L	−52	−50	24	3.98	585
Middle temporal gyrus	L	−30	−68	26	4.94	428
Middle occipital gyrus	R	34	−80	8	4.15	413
Postcentral gyrus	R	52	−8	16	3.46	353
Parahippocampal gyrus	L	−24	−40	−12	3.44	335
Superior temporal gyrus	R	50	6	0	4.59	222
Precuneus	R	2	−68	18	3.49	221
Middle temporal gyrus	L	−44	−62	4	3.78	217
Postcentral gyrus	R	52	−18	32	3.73	217
Medial frontal gyrus	R	4	46	42	3.60	202
Precuneus	L	0	−50	32	3.69	188
Precuneus	L	−16	−76	42	3.43	128
aMCI versus AD
Precuneus	L	0	−70	46	4.19	654
Cerebellum	L	−22	−84	−44	4.75	594
Cerebellum	R	16	−84	−38	3.73	350
Parahippocampal gyrus	L	−26	−8	−18	4.34	345
Middle temporal gyrus	L	−48	−66	22	4.08	306
Superior temporal gyrus	L	−40	18	−28	4.30	185
Healthy subject versus AD
Superior temporal gyrus	R	48	4	2	3.13	20151
Medial frontal gyrus	L	0	54	8	6.54	1411
Cerebellum	L	−24	−76	−50	6.22	957
Parahippocampal gyrus	R	14	−6	−16	6.30	575
Cerebellum	R	20	−86	−40	5.12	564
Parahippocampal gyrus	R	14	−36	2	6.15	490
Medial frontal gyrus	R	20	30	42	4.17	278
Parahippocampal gyrus	R	36	−40	−4	5.11	270
Lentiform Nucleus	R	24	6	20	−5.82	258
Superior frontal gyrus	L	−18	3	44	4.36	230
Caudate	R	10	12	10	6.78	184
Superior temporal gyrus	L	−50	16	−32	4.73	164
Medial frontal gyrus	L	−26	−6	48	4.41	153

Positive values: healthy subjects > aMCI, aMCI > AD, and healthy subjects > AD; Negative values: aMCI > healthy subjects, AD > aMCI, and AD > healthy subjects; Threshold: corrected < 0.05.