Activation of Apoptotic Signal in Endothelial Cells through Intracellular Signaling Molecules Blockade in Tumor-Induced Angiogenesis

Table 1

Nodes, node dependence relations, and corresponding references. The input state combination in each node determines the update rule for that node.

Node	Dependence relation	Reference
Integrin	VE Cadherin and flow	[12–15]
RTK	Flow	[16]
PLC	RTK	[8, 17]
Grb-2/Sos	RTK and Src	[18]
FAK	Integrin	[15, 17, 19, 20]
Src	FAK	[17]
PKC	PLC	[17]
Ras	Grb-2/Sos	[8, 18, 19]
Rho	FAK	[17]
PI3K	Ras and Src	[6, 7]
MEKK	Ras or Rho	[8]
ROCK	Rho	[17]
Rac	Not Rho and PI3K	[6, 7]
Raf-1	Ras and PI3K and PKC	[8, 17, 21, 22]
MEK1/2	Raf-1 or Rac	[17, 23]
Akt	PI3K	[16, 17]
MEK4	MEKK	[8]
Actin	ROCK or Rac	[17]
ERK1/2	MEK1/2	[8, 17]
eNOS	Akt	[16, 17]
JNK	MEK4 and ASK1	[8, 24]
NO	eNOS	[16, 17]
ASK1	Not NO	[25]
Caspase-3	Not NO	[24]
Bad	Not Akt	[24]
Proliferation	ERK1/2	[17, 26]
Apoptosis	Caspase-3 or Bad or JNK	[24]
Migration	Actin	[17]