Research Article

Activation of Apoptotic Signal in Endothelial Cells through Intracellular Signaling Molecules Blockade in Tumor-Induced Angiogenesis

Table 3

EC phenotype classification and fate for inhibition of each intracellular signaling molecule after blood flow. The row corresponding to “None” shows the cell phenotype when no molecules are blocked and EC fate is considered as wild type. The third row shows the abbreviation of each phenotype. P stands for proliferation, A stands for apoptosis, and M stands for motility. One and 0 in each row determine activation and deactivation of each cell phenotype. The last column is EC fate.

Blocked signaling molecule ITG = 1,
RTK = 1,
Cadherin = 0
ITG = 1,
RTK = 1,
Cadherin = 1
EC fate
EC phenotype classification
PAMPAM

None010101Wild type
PLC010001Unable to proliferate
PKC010001Unable to proliferate
Grb-2/Sos010011Apoptosis
Src010011Apoptosis
FAK010010Apoptosis
Ras010011Apoptosis
Rho010101Wild type
Raf-1010001Unable to proliferate
PI3K010011Apoptosis
MEKK010101Wild type
ROCK010100Unable to migrate
Rac010101Wild type
MEK1/2010001Unable to proliferate
Akt010111Apoptosis
MEK4010101Wild type
Actin010100Unable to migrate
eNOS010111Apoptosis
JNK010101Wild type
ERK1/2010001Unable to proliferate
NO010111Apoptosis
ASK1010101Wild type
Caspase-3010101Wild type
Bad010101Wild type