Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2015 (2015), Article ID 913152, 7 pages
http://dx.doi.org/10.1155/2015/913152
Research Article

Antiedematogenic Evaluation of Copaifera langsdorffii Leaves Hydroethanolic Extract and Its Major Compounds

School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, 14040-903 Ribeirão Preto, SP, Brazil

Received 22 February 2015; Accepted 9 April 2015

Academic Editor: Gjumrakch Aliev

Copyright © 2015 Ricardo Andrade Furtado et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. V. F. Veiga Jr. and A. C. Pinto, “O Gênero Copaifera L.,” Química Nova, vol. 25, no. 2, pp. 273–286, 2002. View at Publisher · View at Google Scholar · View at Scopus
  2. A. P. S. Brancalion, R. B. Oliveira, J. P. B. Sousa et al., “Effect of hydroalcoholic extract from Copaifera langsdorffii leaves on urolithiasis induced in rats,” Urological Research, vol. 40, no. 5, pp. 475–481, 2012. View at Publisher · View at Google Scholar · View at Scopus
  3. R. B. de Oliveira, E. B. Coelho, M. R. Rodrigues et al., “Effect of the Copaifera langsdorffii Desf. leaf extract on the ethylene glycol-induced nephrolithiasis in rats,” Evidence-Based Complementary and Alternative Medicine, vol. 2013, Article ID 131372, 10 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  4. J. M. Alves, C. C. Munari, M. de Azevedo Bentes Monteiro Neto et al., “In vivo protective effect of Copaifera langsdorffii hydroalcoholic extract on micronuclei induction by doxorubicin,” Journal of Applied Toxicology, vol. 33, no. 8, pp. 854–860, 2013. View at Publisher · View at Google Scholar · View at Scopus
  5. J. M. Senedese, J. M. Alves, I. M. D. S. Lima et al., “Chemopreventive effect of Copaifera langsdorffii leaves hydroalcoholic extract on 1,2-dimethylhydrazine-induced DNA damage and preneoplastic lesions in rat colon,” BMC Complementary and Alternative Medicine, vol. 13, article 3, 2013. View at Publisher · View at Google Scholar · View at Scopus
  6. R. L. Fabri, R. A. Garcia, J. R. Florêncio et al., “Anti-inflammatory and antioxidative effects of the methanolic extract of the aerial parts of Mitracarpus frigidus in established animal models,” Journal of Pharmacy and Pharmacology, vol. 66, no. 5, pp. 722–732, 2014. View at Publisher · View at Google Scholar · View at Scopus
  7. M. Zimmermann, “Ethical guidelines for investigations of experimental pain in conscious animals,” Pain, vol. 16, no. 2, pp. 109–110, 1983. View at Publisher · View at Google Scholar · View at Scopus
  8. P. A. Botham, “Acute systemic toxicity—prospects for tiered testing strategies,” Toxicology in Vitro, vol. 18, no. 2, pp. 227–230, 2004. View at Publisher · View at Google Scholar · View at Scopus
  9. R. Koster, M. Anderson, and E. J. Beer, “Acetic acid for analgesic screening,” Federation Proceedings, vol. 18, pp. 412–416, 1959. View at Google Scholar
  10. J. H. Rosland, A. Tjolsen, B. Maehle, and K. Hole, “The formalin test in mice: effect of formalin concentration,” Pain, vol. 42, no. 2, pp. 235–242, 1990. View at Publisher · View at Google Scholar · View at Scopus
  11. P. Antonisamy, V. Duraipandiyan, and S. Ignacimuthu, “Anti-inflammatory, analgesic and antipyretic effects of friedelin isolated from Azima tetracantha Lam. in mouse and rat models,” Journal of Pharmacy and Pharmacology, vol. 63, no. 8, pp. 1070–1077, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. S. H. Ferreira, “A new method for measuring variations of rat paw volume,” Journal of Pharmacy and Pharmacology, vol. 31, article 648, 1979. View at Publisher · View at Google Scholar · View at Scopus
  13. G. E. P. de Souza and S. H. Ferreira, “Blockade by antimacrophage serum of the migration of PMN neutrophils into the inflamed peritoneal cavity,” Agents and Actions, vol. 17, no. 1, pp. 97–103, 1985. View at Publisher · View at Google Scholar · View at Scopus
  14. K. F. Zoccal, C. d. Bitencourt, F. W. Paula-Silva et al., “TLR2, TLR4 and CD14 recognize venom-associated molecular patterns from tityus serrulatus to induce macrophage-derived inflammatory mediators,” PLoS ONE, vol. 9, no. 2, Article ID e88174, 2014. View at Publisher · View at Google Scholar
  15. T. Mosmann, “Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays,” Journal of Immunological Methods, vol. 65, no. 1-2, pp. 55–63, 1983. View at Publisher · View at Google Scholar · View at Scopus
  16. A. Ding, C. F. Nathan, J. Graycar, R. Derynck, D. J. Stuehr, and S. Srimal, “Macrophage deactivating factor and transforming growth factors-β1, -β2, and -β3 inhibit induction of macrophage nitrogen oxide synthesis by IFN-γ,” The Journal of Immunology, vol. 145, no. 3, pp. 940–944, 1990. View at Google Scholar · View at Scopus
  17. A. Nugroho, J.-K. Choi, J.-H. Park, K.-T. Lee, B. C. Cha, and H.-J. Park, “Two new flavonol glycosides from Lamium amplexicaule L. and their in vitro free radical scavenging and tyrosinase inhibitory activities,” Planta Medica, vol. 75, no. 4, pp. 364–366, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. A. C. P. Oliveira, C. M. Bertollo, L. T. S. Rocha, E. B. Nascimento Jr., K. A. Costa, and M. M. Coelho, “Antinociceptive and antiedematogenic activities of fenofibrate, an agonist of PPAR alpha, and pioglitazone, an agonist of PPAR gamma,” European Journal of Pharmacology, vol. 561, no. 1–3, pp. 194–201, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. M. Taghi Mansouri, B. Naghizadeh, B. Ghorbanzadeh, and Y. Farbood, “Central and peripheral antinociceptive effects of ellagic acid in different animal models of pain,” European Journal of Pharmacology, vol. 707, no. 1–3, pp. 46–53, 2013. View at Publisher · View at Google Scholar · View at Scopus
  20. H. O. J. Collier, L. C. Dinneen, C. A. Johnson, and C. Schneider, “The abdominal constriction response and its suppression by analgesic drugs in the mouse,” British Journal of Pharmacology, vol. 32, no. 2, pp. 295–310, 1968. View at Google Scholar · View at Scopus
  21. D. Kempuraj, B. Madhappan, S. Christodoulou et al., “Flavonols inhibit proinflammatory mediator release, intracellular calcium ion levels and protein kinase C theta phosphorylation in human mast cells,” British Journal of Pharmacology, vol. 145, no. 7, pp. 934–944, 2005. View at Publisher · View at Google Scholar · View at Scopus
  22. J. P. Brown and P. S. Dietrich, “Mutagenicity of plant flavonols in the Salmonella/mammalian microsome test. Activation of flavonol glycosides by mixed glycosidases from rat cecal bacteria and other sources,” Mutation Research/Genetic Toxicology, vol. 66, no. 3, pp. 223–240, 1979. View at Publisher · View at Google Scholar · View at Scopus
  23. M. V. Medeiros, I. M. Binhara, H. Moreno Jr., R. Zatz, G. de Nucci, and E. Antunes, “Effect of chronic nitric oxide synthesis inhibition on the inflammatory responses induced by carrageenin in rats,” European Journal of Pharmacology, vol. 285, no. 2, pp. 109–114, 1995. View at Publisher · View at Google Scholar · View at Scopus
  24. R. A. A. Mothana, “Anti-inflammatory, antinociceptive and antioxidant activities of the endemic Soqotraen Boswellia elongata Balf. f. and Jatropha unicostata Balf. f. in different experimental models,” Food and Chemical Toxicology, vol. 49, no. 10, pp. 2594–2599, 2011. View at Publisher · View at Google Scholar · View at Scopus
  25. J. P. van Wauwe and J. G. Goossens, “Arabinogalactan- and dextran-induced ear inflammation in mice: differential inhibition by H1-antihistamines, 5-HT-serotonin antagonists and lipoxygenase blockers,” Agents and Actions, vol. 28, no. 1-2, pp. 78–82, 1989. View at Publisher · View at Google Scholar · View at Scopus
  26. R. A. Stokbroekx, M. G. M. Luyckx, J. J. M. Willems, J. O. Bracke, R. Joossen, and J. P. van Wauwe, “Levocabastine (R 50547): the prototype of a chemical series of compounds with specific H1-antihistaminic activity,” Drug Development Research, vol. 8, no. 1–4, pp. 87–93, 1986. View at Publisher · View at Google Scholar · View at Scopus
  27. S. Moncada, R. M. J. Palmer, and E. A. Higgs, “Nitric oxide: physiology, pathophysiology, and pharmacology,” Pharmacological Reviews, vol. 43, no. 2, pp. 109–142, 1991. View at Google Scholar · View at Scopus
  28. H. Loppnow, P. Libby, M. Freudenberg, J. H. Krauss, J. Weckesser, and H. Mayer, “Cytokine induction by lipopolysaccharide (LPS) corresponds to lethal toxicity and is inhibited by nontoxic Rhodobacter capsulatus LPS,” Infection and Immunity, vol. 58, no. 11, pp. 3743–3750, 1990. View at Google Scholar · View at Scopus