The Application of Classification and Regression Trees for the Triage of Women for Referral to Colposcopy and the Estimation of Risk for Cervical Intraepithelial Neoplasia: A Study Based on 1625 Cases with Incomplete Data from Molecular Tests

Table 4

Performance of CART and individual examinations.

	CART	Cytology using cutoff ASC-US+	Cytology using cutoff ASC-H+	Arrays (positive if any type was found)	Arrays (positive if a high risk type was found)	Arrays (positive if subtype 16 or 18 was found)	NASBA (positive if any type was found)	Flow cytometry (positive if the result is positive >1.5%)	p16
Sensitivity	83.28%	97.76%	69.33%	87.71%	84.72%	52.82%	69.65%	88.19%	57.21%
Specificity	94.26%	59.79%	95.04%	70.49%	75.02%	90.28%	87.09%	79.60%	93.57%
PPV	79.04%	37.82%	77.78%	42.86%	46.11%	57.82%	62.15%	48.49%	69.68%
NPV	95.60%	99.07%	92.53%	95.79%	95.11%	88.35%	90.41%	96.87%	89.44%
FPR	5.74%	40.21%	4.96%	29.51%	24.98%	9.72%	12.91%	20.40%	6.43%
FNR	16.72%	2.24%	30.67%	12.29%	15.28%	47.18%	30.35%	11.81%	42.79%
OA	92.00%	67.39%	89.90%	73.96%	76.97%	82.73%	83.02%	81.13%	86.11%
Valid results	1625	1564	1564	1494	1494	1494	1101	1325	1116
% of valid results	100.00%	96.25%	96.25%	91.94%	91.94%	91.94%	67.75%	81.54%	68.68%