The Gastrointestinal Irritation of Polygala Saponins and Its Potential Mechanism In Vitro and In Vivo

Figure 5

Influence of polygala saponins with different glycosyls on gastric TNF-α levels in mice. Mark: mice were, respectively, administrated by intragastrical administration (I.G) with the doses (200 mg/kg) of Onjisaponin B (OJB), tenuifolin (TEN), and senegenin (SNG). Negative control groups were treated with equal volume of vehicle. After the gastrointestinal tissues in mice were homogenized, we determine TNF-α levels of gastric homogenate. Each column is mean ± standard deviation for 10 mice in each group.