Review Article

Phytochemical Compounds and Protection from Cardiovascular Diseases: A State of the Art

Table 2

Clinical effects of vegetable compounds.

VegetableClinical effectsReference

Resveratrol(i) Decreases SBP without affecting DBP[37]
(ii) Enhances Ach-mediated vasorelaxation in hypertensive and dyslipidemic pts[38]
(iii) Improves FMD in pts with either metabolic syndrome or previous MI[39, 40]
(iv) Decreases total cholesteroland total and ox-LDL, triglycerides, and ApoB levels in pts with T2DM, CAD, hyperlipidemia, and other CV risk factors[53, 54]
(v) Improves insulin sensitivity in both obese and metabolic syndrome pts[66, 67]
(vi) Improves significantly diastolic function and modestly systolic function in pts with previous MI[40]

Brassica oleracea (i) Reduces total, LDL cholesterol and markers of oxidative stress in smokers and hypercholesterolemic pts[108, 119]
(ii) Improves lipid profiles and ox-LDL/LDL cholesterol ratio in T2DM pts[132]
(iii) Lowers arterial stiffness and central BP in women[133]

Curcumin(i) Decreases both total and LDL cholesterol and increases HDL cholesterol in healthy subjects and in ACS pts[164, 165]
(ii) Increases FMD in postmenopausal women[168]

Berberine(i) Increases both LVEF and exercise capacity and decreases rates of ventricular premature complexes and long-term mortality in HF pts[199]
(ii) Reduces total cholesterol, triglycerides, and LDL cholesterol levels and modestly increases HDL cholesterol in hyperlipidemic and T2DM pts[203, 205]
(iii) Reduces glycated hemoglobin, fasting plasma insulin, postprandial glucose, and fasting plasma glucose in T2DM pts[204]
(iv) Lowers SBP and DBP in hypertensive, T2DM, and hyperlipidemic pts[206]

SBP: systolic blood pressure; DBP: diastolic blood pressure; Ach: Acetylcholine; FMD: flow-mediated dilation; MI: myocardial infarction; ox-LDL: oxidized low-density lipoprotein; HDL: high-density lipoprotein; Apo: apolipoprotein; T2DM: type 2 diabetes mellitus; CAD: coronary artery disease; CV: cardiovascular; ACS: acute coronary syndrome; LVEF: left ventricular ejection fraction; HF: heart failure; pts: patients.